Movement-related cortical potentials underlying motor preparation and execution in children with attention-deficit/hyperactivity disorder

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology Pub Date : 2025-04-06 DOI:10.1016/j.clinph.2025.03.045

Marija Pranjić , Virginia Peisch , Gaelle Gourdet , Matthew Zimon , Anne B. Arnett

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引用次数: 0

Abstract

Objective

Motor control difficulties are highly common in Attention-Deficit/Hyperactivity Disorder (ADHD), yet the etiology of this comorbidity remains unclear. We examined (1) whether children with ADHD have atypical movement-related cortical potentials (MRCPs) during movement preparation and/or execution compared to typically developing (TD) children, and (2) whether MRCPs associated with visual-motor performance and ADHD symptoms overlap.

Methods

MRCPs and visual-motor integration (VMI) were measured among 66 right-handed children with ADHD and 30 TD children (ages 7–11 years). Caregivers reported on ADHD symptoms. MRCPs were extracted over fronto-central scalp regions during two ERP tasks requiring button presses.

Results

Children with ADHD had lower accuracy on MRCP tasks and reduced VMI scores, compared to TDs. ADHD diagnosis was associated with attenuated correct trial MRCP amplitudes at a fronto-midline electrode during movement preparation, but not execution. ADHD symptom severity and reduced error trial MRCP amplitudes each explained unique variance in VMI performance.

Conclusions

Pediatric ADHD is associated with atypical cortical activity during movement preparation, but not execution. VMI performance and ADHD diagnosis were associated with distinct motor cortical processes, providing support for the separate etiology hypothesis.

Significance

Motor difficulties in children with ADHD may require an intervention approach that is distinct from the treatment of core ADHD symptoms.

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来源期刊

Clinical Neurophysiology 医学-临床神经学

CiteScore

8.70

自引率

6.40%

发文量

932

审稿时长

59 days

期刊介绍： As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology. Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.