Therapeutic potential of microRNA in meniscal repair and regeneration

IF 1.6 4区医学 Q3 ORTHOPEDICS

Knee Pub Date : 2025-04-10 DOI:10.1016/j.knee.2025.03.002

George Jacob , Kazunori Shimomura , Hiroto Hanai , Taro Akimori , Tomoki Ohori , Akira Tsujii , Yu Moriguchi , Norimasa Nakamura

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引用次数: 0

Abstract

Background

Managing meniscal injuries is challenging due to the complex nature of the tissue and its limited healing capacity. MicroRNAs (miRNAs) are key regulators of cellular processes, making them promising candidates for therapeutic interventions aimed at enhancing meniscal repair. This study explores the potential role of miRNAs in meniscal healing.

Methods

A comprehensive literature search was conducted in July 2024 using the PubMed (MEDLINE) and EMBASE databases, without any date restrictions. Relevant studies involving the use of miRNAs in meniscal injury or repair were identified, and a narrative review was performed.

Results

The search yielded three in-vitro studies and one animal study, with no clinical studies found. The identified studies suggest that miRNAs may enhance meniscal healing by promoting angiogenesis and reducing inflammation.

Conclusions

This review underscores the emerging potential of miRNA-based therapies for meniscal repair and regeneration. While progress has been made in understanding the mechanisms of action, several challenges remain before clinical application, including safety concerns, the need for standardized protocols, and the development of clinical-grade miRNA products.

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来源期刊

Knee 医学-外科

CiteScore

3.80

自引率

5.30%

发文量

171

审稿时长

6 months

期刊介绍： The Knee is an international journal publishing studies on the clinical treatment and fundamental biomechanical characteristics of this joint. The aim of the journal is to provide a vehicle relevant to surgeons, biomedical engineers, imaging specialists, materials scientists, rehabilitation personnel and all those with an interest in the knee. The topics covered include, but are not limited to: • Anatomy, physiology, morphology and biochemistry; • Biomechanical studies; • Advances in the development of prosthetic, orthotic and augmentation devices; • Imaging and diagnostic techniques; • Pathology; • Trauma; • Surgery; • Rehabilitation.