Efficient in-droplet concentration of particles for digital microfluidics on coplanar electrodes by integrating electrowetting-on-dielectric (EWOD) and surface acoustic wave (SAW) technologies

IF 8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Sensors and Actuators B: Chemical Pub Date : 2025-04-08 DOI:10.1016/j.snb.2025.137765

Chun-Hong Chen , Kai-Hsiang Yang

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引用次数: 0

Abstract

Recently, few medical applications have employed coplanar electrodes for digital microfluidics (DMF), as DMF manipulation on coplanar electrodes requires high operation voltage. In this study, we present the first device of in-droplet particle concentration and droplet splitting on coplanar electrodes by integrating surface acoustic wave (SAW) and electrowetting-on-dielectric (EWOD) technologies. In our device, particles are concentrated on one side of the droplet by SAW, with subsequent droplet cutting by EWOD. In addition, quantitative analysis was used to evaluate the method, and showed that 97.8 % of particles can be concentrated. Compared to traditional parallel-plate EWOD and SAW devices, our novel device can provide high concentration efficiency and simple fabrication (without a top plate and microchannel) in digital microfluidics. The novel in-droplet concentration and droplet cutting method could integrate many particle assays and digital microfluidics on coplanar electrodes to extend their applications.

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通过集成电介质电润湿（EWOD）和表面声波（SAW）技术，在共面电极上实现数字微流体的高效液滴内颗粒浓缩

由于在共面电极上操作数字微流控技术需要较高的工作电压，目前在医学上应用共面电极的数字微流控技术很少。在这项研究中，我们提出了一种结合表面声波（SAW）和介质电润湿（EWOD）技术的共面电极上的液滴内粒子浓度和液滴分裂装置。在我们的装置中，颗粒通过SAW集中在液滴的一侧，随后通过EWOD切割液滴。此外，通过定量分析对该方法进行了评价，结果表明，该方法可浓缩97.8%的颗粒。与传统的平行板EWOD和SAW器件相比，该器件具有浓缩效率高、制造简单（无顶板和微通道）的特点。这种新型的液滴浓缩和液滴切割方法可以将多种粒子分析和数字微流控技术集成在共面电极上，以扩展其应用范围。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Sensors and Actuators B: Chemical 工程技术-电化学

CiteScore

14.60

自引率

11.90%

发文量

1776

审稿时长

3.2 months

期刊介绍： Sensors & Actuators, B: Chemical is an international journal focused on the research and development of chemical transducers. It covers chemical sensors and biosensors, chemical actuators, and analytical microsystems. The journal is interdisciplinary, aiming to publish original works showcasing substantial advancements beyond the current state of the art in these fields, with practical applicability to solving meaningful analytical problems. Review articles are accepted by invitation from an Editor of the journal.