Site-directed antibody conjugation via ubiquitination

IF 26.8 1区医学 Q1 ENGINEERING, BIOMEDICAL

Nature Biomedical Engineering Pub Date : 2025-04-09 DOI:10.1038/s41551-025-01368-x

引用次数: 0

Abstract

The method uses ubiquitin biochemistry in vitro to achieve rapid and site-specific protein conjugation to generate homogeneous multimeric antibody conjugates. It addresses limitations of traditional conjugation methods, and it may aid the development of antibody therapies and vaccines.

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该方法在体外利用泛素生物化学作用实现快速和特定位点的蛋白质共轭，生成同质的多聚抗体共轭物。它解决了传统共轭方法的局限性，有助于抗体疗法和疫苗的开发。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Biomedical Engineering Medicine-Medicine (miscellaneous)

CiteScore

45.30

自引率

1.10%

发文量

138

期刊介绍： Nature Biomedical Engineering is an online-only monthly journal that was launched in January 2017. It aims to publish original research, reviews, and commentary focusing on applied biomedicine and health technology. The journal targets a diverse audience, including life scientists who are involved in developing experimental or computational systems and methods to enhance our understanding of human physiology. It also covers biomedical researchers and engineers who are engaged in designing or optimizing therapies, assays, devices, or procedures for diagnosing or treating diseases. Additionally, clinicians, who make use of research outputs to evaluate patient health or administer therapy in various clinical settings and healthcare contexts, are also part of the target audience.