Diffusion imaging in gliomas: how ADC values forecast glioma genetics.

Abstract

Purpose: This study investigates the relationship between diffusion-weighted imaging (DWI) and mean apparent diffusion coefficient (ADC) values in predicting the genetic and molecular features of gliomas. The goal is to enhance non-invasive diagnostic methods and support personalised treatment strategies by clarifying the association between imaging biomarkers and tumour genotypes.

Material and methods: A total of 91 glioma patients treated between August 2023 and March 2024 were included in the analysis. All patients underwent preoperative magnetic resonance imaging (MRI), including DWI, and had available histopathological and genetic test results. Clinical data, tumour characteristics, and genetic markers such as IDH1 mutation, MGMT promoter methylation, EGFR amplification, TERT pathogenic variant, and CDKN2A deletion were collected. Statistical analysis was performed to identify correlations between ADC values, MRI perfusion parameters, and genetic characteristics.

Results: Significant associations were found between lower ADC values and aggressive tumour features, including IDH1-wildtype, MGMT unmethylated status, TERT pathogenic variant, and EGFR amplification. Additionally, distinct ADC patterns were observed in gliomas with CDKN2A, TP53, and PTEN gene deletions. These findings were further supported by contrast enhancement and other MRI parameters, indicating their role in tumour characterisation.

Conclusions: DWI and ADC measurements demonstrate strong potential as non-invasive tools for predicting glioma genetics. These imaging biomarkers can aid in tumour characterisation and provide valuable insights for guiding personalised treatment strategies.