[Bone mineral density assessment of women on long-term antiepileptic therapy].

Q3 Medicine

Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova Pub Date : 2025-01-01 DOI:10.17116/jnevro2025125031112

D Yu Yusupova, F Kh Muratov

{"title":"[Bone mineral density assessment of women on long-term antiepileptic therapy].","authors":"D Yu Yusupova, F Kh Muratov","doi":"10.17116/jnevro2025125031112","DOIUrl":null,"url":null,"abstract":"Objective: To study the effect of anticonvulsants on bone mineral density in patients with epilepsy.Material and methods: The study included 90 women with epilepsy and a control group of 60 healthy women. The subjects' serum levels of parathyroid hormone, alkaline phosphatase, calcium, phosphorus, and vitamin D were measured. Mineral density and bone structure were assessed using dual-energy X-ray absorptiometry (DEXA).Results: In women with epilepsy, the serum levels of calcium, phosphorus, and vitamin D were significantly lower compared to the control group, and the levels of parathyroid hormone and alkaline phosphatase were significantly higher. There was also a statistically significant difference in the DEXA values between study groups. In women with epilepsy who received enzyme-inducing antiepileptic drugs, calcium, phosphorus, and vitamin D levels were significantly lower compared to patients who received enzyme-inhibiting antiepileptic drugs. Bone mineral density was positively correlated with serum micronutrients (calcium, phosphorus, vitamin D) and negatively with serum alkaline phosphatase and duration of therapy.Conclusion: Bone tissue disorders are common in patients with epilepsy. These disorders may be associated with prolonged use of antiepileptic drugs, especially enzyme inducers.","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"125 3","pages":"112-116"},"PeriodicalIF":0.0000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.17116/jnevro2025125031112","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

Abstract

Objective: To study the effect of anticonvulsants on bone mineral density in patients with epilepsy.

Material and methods: The study included 90 women with epilepsy and a control group of 60 healthy women. The subjects' serum levels of parathyroid hormone, alkaline phosphatase, calcium, phosphorus, and vitamin D were measured. Mineral density and bone structure were assessed using dual-energy X-ray absorptiometry (DEXA).

Results: In women with epilepsy, the serum levels of calcium, phosphorus, and vitamin D were significantly lower compared to the control group, and the levels of parathyroid hormone and alkaline phosphatase were significantly higher. There was also a statistically significant difference in the DEXA values between study groups. In women with epilepsy who received enzyme-inducing antiepileptic drugs, calcium, phosphorus, and vitamin D levels were significantly lower compared to patients who received enzyme-inhibiting antiepileptic drugs. Bone mineral density was positively correlated with serum micronutrients (calcium, phosphorus, vitamin D) and negatively with serum alkaline phosphatase and duration of therapy.

Conclusion: Bone tissue disorders are common in patients with epilepsy. These disorders may be associated with prolonged use of antiepileptic drugs, especially enzyme inducers.

查看原文本刊更多论文

[长期抗癫痫治疗妇女的骨密度评估]。

目的：研究抗惊厥药对癫痫患者骨矿物质密度的影响：研究抗惊厥药对癫痫患者骨矿物质密度的影响：研究对象包括 90 名女性癫痫患者和 60 名健康女性对照组。测量受试者血清中甲状旁腺激素、碱性磷酸酶、钙、磷和维生素 D 的水平。使用双能 X 射线吸收测量法（DEXA）对矿物质密度和骨结构进行了评估：结果：与对照组相比，女性癫痫患者血清中钙、磷和维生素 D 的水平明显较低，而甲状旁腺激素和碱性磷酸酶的水平则明显较高。研究组之间的 DEXA 值差异也有统计学意义。与服用酶抑制型抗癫痫药物的患者相比，服用酶诱导型抗癫痫药物的女性癫痫患者的钙、磷和维生素D水平明显较低。骨矿物质密度与血清微量元素（钙、磷、维生素 D）呈正相关，与血清碱性磷酸酶和治疗时间呈负相关：结论：骨组织病变在癫痫患者中很常见。这些疾病可能与长期服用抗癫痫药物（尤其是酶诱导剂）有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova 医学-精神病学

CiteScore

1.10

自引率

0.00%

发文量

287

审稿时长

3-6 weeks

期刊介绍： Одно из старейших медицинских изданий России, основанное в 1901 году. Создание журнала связано с именами выдающихся деятелей отечественной медицины, вошедших в историю мировой психиатрии и неврологии, – С.С. Корсакова и А.Я. Кожевникова. Широкий диапазон предлагаемых журналом материалов и разнообразие форм их представления привлекают внимание научных работников и врачей, опытных и начинающих медиков, причем не только неврологов и психиатров, но и специалистов смежных областей медицины.