Impact of Transcutaneous Vagus Nerve Stimulation on Event-related Potentials during a Response Inhibition Task

IF 3 3区医学 Q2 NEUROSCIENCES

Journal of Cognitive Neuroscience Pub Date : 2025-09-08 DOI:10.1162/jocn_a_02332

Piaoyi Li;Xiaojiaoyang Li;Ruihua Liu;Huijuan Zhang;Dong Song;Jin Cao

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Abstract

As an emerging neuromodulation technique, transcutaneous auricular vagus nerve stimulation (taVNS) has shown promise in enhancing cognitive abilities. The present study used a combination of the go/no-go task and the stop-signal task experimental paradigm to examine the cognitive effects of taVNS on participants' EEG measures. Sixty-one healthy participants were randomly assigned to either the stimulation group or the sham group. Participants in the stimulation group received 100 Hz and 25 Hz stimulation in a counterbalanced order. We compared behavioral and EEG data before and after stimulation, and observed significant effects. The findings revealed that a 100-Hz taVNS significantly reduced participants' N2 latency in the stop trial, indicating potential improvement response inhibition. In addition, we noted a decreasing trend in alpha, theta, and delta band power during response inhibition after receiving a 100-Hz taVNS. These results suggest that a 100-Hz taVNS can enhance participants' response inhibition abilities, indicating its potential as a therapeutic approach for modulating cognitive functions.

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经皮迷走神经刺激对反应抑制任务中事件相关电位的影响。

经皮耳迷走神经刺激（taVNS）作为一种新兴的神经调节技术，在增强认知能力方面显示出良好的前景。本研究采用走/不走任务和停止信号任务相结合的实验范式，考察了taVNS对参与者脑电图测量的认知影响。61名健康参与者被随机分配到刺激组和假手术组。刺激组的参与者以平衡的顺序接受100赫兹和25赫兹的刺激。我们比较刺激前后的行为和脑电图数据，观察到明显的效果。研究结果显示，100 hz的taVNS显著降低了停止试验中参与者的N2潜伏期，表明可能改善反应抑制。此外，我们注意到在接受100 hz taVNS后，在响应抑制期间α， θ和δ波段功率呈下降趋势。这些结果表明，100 hz的taVNS可以增强参与者的反应抑制能力，表明其作为调节认知功能的治疗方法的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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