{"title":"Impact of liver transplantation on the quality of life of a cohort of high-risk recipients.","authors":"Heloisa Barboza Paglione, Daisa de Mesquita Escobosa, Beatriz Mesquita Pimenta, Bianca Della-Guardia, Amanda Pinter Carvalheiro da Silva Boteon, Yuri Longatto Boteon","doi":"10.31744/einstein_journal/2025AO0565","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Liver transplantation significantly improves the health-related quality of life of patients with cirrhosis and high MELD scores. This study highlights rapid health-related quality of life gains after transplantation that were sustained during the one-year follow-up period, emphasizing the role of multidisciplinary care in achieving these outcomes.</p><p><strong>Objective: </strong>To assess the effects of liver transplantation on the health-related quality of life of patients with cirrhosis on the waiting list for transplantation.</p><p><strong>Methods: </strong>This retrospective study analyzed HRQOL using the EQ-5D questionnaire before (T0), and 3 (T3), 6 (T6), and 12 (T12) months after, transplantation. The questionnaire comprised five health status scores, which were also combined into a single utility score. Changes in each dimension and in the utility score were examined.</p><p><strong>Results: </strong>A total of 212 patients were included in the study, with a mean age of 54 (SD, 12) years, and a median Model for End-Stage Liver Disease score of 17 (Q1= 11; Q3= 24). The most frequent etiology was chronic alcoholism (26.9%). Improvements in EQ-5D utility scores were registered at all post-transplantation time points compared to the score at T0: an increase of 0.22 points (p<0.001) at T3, 0.27 (p<0.001) at T6, and 0.268 (p<0.001) at T12. Scores increased over time in all domains of the EQ-5D.</p><p><strong>Conclusion: </strong>In a large sample of high-risk transplant recipients, a significant improvement in HRQOL occurred three months after transplantation, and was sustained over the one-year follow-up period.</p><p><strong>Background: </strong>■ Liver transplantation improves health-related quality of life in patients with cirrhosis and high MELD scores.</p><p><strong>Background: </strong>■ Significant health-related quality of life improvements occur within three months of transplantation.</p><p><strong>Background: </strong>■ Multidisciplinary care programs enhance post-iver transplantation physical and mental recovery.</p><p><strong>Background: </strong>■ Sustained health-related quality of life gains highlight the long-term benefits of liver transplantation.</p>","PeriodicalId":47359,"journal":{"name":"Einstein-Sao Paulo","volume":"23 ","pages":"eAO0565"},"PeriodicalIF":1.1000,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Einstein-Sao Paulo","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.31744/einstein_journal/2025AO0565","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
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Abstract
Background: Liver transplantation significantly improves the health-related quality of life of patients with cirrhosis and high MELD scores. This study highlights rapid health-related quality of life gains after transplantation that were sustained during the one-year follow-up period, emphasizing the role of multidisciplinary care in achieving these outcomes.
Objective: To assess the effects of liver transplantation on the health-related quality of life of patients with cirrhosis on the waiting list for transplantation.
Methods: This retrospective study analyzed HRQOL using the EQ-5D questionnaire before (T0), and 3 (T3), 6 (T6), and 12 (T12) months after, transplantation. The questionnaire comprised five health status scores, which were also combined into a single utility score. Changes in each dimension and in the utility score were examined.
Results: A total of 212 patients were included in the study, with a mean age of 54 (SD, 12) years, and a median Model for End-Stage Liver Disease score of 17 (Q1= 11; Q3= 24). The most frequent etiology was chronic alcoholism (26.9%). Improvements in EQ-5D utility scores were registered at all post-transplantation time points compared to the score at T0: an increase of 0.22 points (p<0.001) at T3, 0.27 (p<0.001) at T6, and 0.268 (p<0.001) at T12. Scores increased over time in all domains of the EQ-5D.
Conclusion: In a large sample of high-risk transplant recipients, a significant improvement in HRQOL occurred three months after transplantation, and was sustained over the one-year follow-up period.
Background: ■ Liver transplantation improves health-related quality of life in patients with cirrhosis and high MELD scores.
Background: ■ Significant health-related quality of life improvements occur within three months of transplantation.
Background: ■ Multidisciplinary care programs enhance post-iver transplantation physical and mental recovery.
Background: ■ Sustained health-related quality of life gains highlight the long-term benefits of liver transplantation.
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