The use of brain-machine interface, motor imagery, and action observation in the rehabilitation of individuals with Parkinson's disease: A protocol study for a randomized clinical trial.

IF 2.9 3区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

PLoS ONE Pub Date : 2025-04-07 eCollection Date: 2025-01-01 DOI:10.1371/journal.pone.0315148

Kátine Marchezan Estivalet, Tatiana Salayaran de Aguiar Pettenuzzo, Natália Lopes Mazzilli, Luis Fernando Ferreira, Fernanda Cechetti

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引用次数: 0

Abstract

Background: Parkinson's disease (PD) is a neurodegenerative condition that impacts motor planning and control of the upper limbs (UL) and leads to cognitive impairments. Rehabilitation approaches, including motor imagery (MI) and action observation (AO), along with the use of brain-machine interfaces (BMI), are essential in the PD population to enhance neuroplasticity and mitigate symptoms.

Objective: To provide a description of a rehabilitation protocol for evaluating the effects of isolated and combined applications of MI and action observation (AO), along with BMI, on upper limb (UL) motor changes and cognitive function in PD.

Methods: This study provides a detailed protocol for a single-blinded, randomized clinical trial. After selection, participants will be randomly assigned to one of five experimental groups. Each participant will be assessed at three points: pre-intervention, post-intervention, and at a follow-up four weeks after the intervention ends. The intervention consists of 10 sessions, each lasting approximately 60 minutes.

Expected results: The primary outcome expected is an improvement in the Test d'Évaluation des Membres Supérieurs de Personnes Âgées score, accompanied by a reduction in task execution time. Secondary outcomes include motor symptoms in the upper limbs, assessed via the Unified Parkinson's Disease Rating Scale - Part III and the 9-Hole Peg Test; cognitive function, assessed with the PD Cognitive Rating Scale; and occupational performance, assessed with the Canadian Occupational Performance Measure.

Discussion: This study protocol is notable for its intensive daily sessions. Both MI and AO are low-cost, enabling personalized interventions that physiotherapists and occupational therapists can readily replicate in practice. While BMI use does require professionals to acquire an exoskeleton, the protocol ensures the distinctiveness of the interventions and, to our knowledge, is the first to involve individuals with PD.

Trial registration: ClinicalTrials.gov NCT05696925.

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脑机接口、运动图像和动作观察在帕金森病患者康复中的应用：一项随机临床试验的方案研究

背景：帕金森病（PD）是一种神经退行性疾病，影响上肢运动规划和控制（UL）并导致认知障碍。包括运动意象（MI）和动作观察（AO）在内的康复方法，以及脑机接口（BMI）的使用，对于PD患者增强神经可塑性和减轻症状至关重要。目的：提供一种康复方案，用于评估单独或联合应用MI和动作观察（AO）以及BMI对PD患者上肢（UL）运动改变和认知功能的影响。方法：本研究为单盲、随机临床试验提供了详细的方案。选择后，参与者将被随机分配到五个实验组之一。每位参与者将在三个时间点接受评估：干预前、干预后以及干预结束后四周的随访。干预包括10个环节，每个环节持续约60分钟。预期结果：预期的主要结果是在Test d'Évaluation des members supsamrieurs de Personnes Âgées得分有所提高，同时任务执行时间也有所减少。次要结局包括上肢运动症状，通过统一帕金森病评定量表-第三部分和9孔钉试验评估；认知功能，用PD认知评定量表评估；和职业表现，用加拿大职业表现量表评估。讨论：该研究方案以其密集的每日会议而闻名。MI和AO都是低成本的，使得物理治疗师和职业治疗师可以在实践中很容易地复制个性化干预。虽然使用BMI确实需要专业人员获得外骨骼，但该方案确保了干预措施的独特性，据我们所知，这是第一个涉及PD患者的方案。试验注册：ClinicalTrials.gov NCT05696925。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

PLoS ONE 生物-生物学

CiteScore

6.20

自引率

5.40%

发文量

14242

审稿时长

3.7 months

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