A Dual-Center Study of Retinal Detachment Following Endogenous Endophthalmitis.

IF 2.6 4区医学 Q2 OPHTHALMOLOGY

Ocular Immunology and Inflammation Pub Date : 2025-04-07 DOI:10.1080/09273948.2025.2489527

Peter J Weng, Richmond Woodward, Walter Duy, Henry Feng, Margaret Greven, Sharon Fekrat

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Abstract

Purpose: To evaluate factors associated with increased odds of retinal detachment (RD) following endogenous endophthalmitis (EE).

Methods: Retrospective study of individuals with EE from two tertiary care centers. Demographics, medical and ocular history, presenting clinical features, microbial cultures, and initial management were assessed in relation to subsequent RD.

Results: Of 93 study eyes, 30 (32.3%) diagnosed with EE developed subsequent RD. Compared with eyes that did not develop subsequent RD, eyes that developed RD had lower intraocular pressure (IOP) at presentation (RD: 14.0 ± 6.5 mm Hg vs. no RD: 17.3 ± 7.7 mm Hg, p = 0.02) and had higher rates of methicillin-resistant Staphylococcus aureus (MRSA) positive blood cultures (RD: (13/30) 43.3% vs no RD: (9/63) 14.3%, p = 0.004). The number of intravitreal injections was higher in eyes that developed subsequent RD compared to eyes that did not (RD: 5.3 ± 3.3 vs. no RD: 3.9 ± 3.0, p = 0.02), while no difference in subsequent RD was noted in eyes receiving therapeutic vitrectomy (p = 0.19). After controlling for age, sex, and duration of follow-up, lower IOP at presentation and MRSA positive blood cultures were associated with significantly higher odds of subsequent RD.

Conclusion: Eyes with lower IOP at presentation and positive MRSA blood cultures were associated with higher rates of subsequent RD, even after controlling for age, sex, and duration of follow-up. Longer follow-up of patients with EE with MRSA bacteremia may be warranted, and larger cohort studies to identify additional features associated with RD are needed.

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内源性眼内炎后视网膜脱离的双中心研究。

目的：评估内源性眼内炎（EE）后视网膜脱离（RD）几率增加的相关因素。方法：对来自两个三级医疗中心的情感表达患者进行回顾性研究。研究人员评估了与随后RD相关的人口统计学、医学和眼史、临床特征、微生物培养和初始处理。结果：在93只研究眼睛中，30只（32.3%）被诊断为EE的眼睛发生了随后的RD。与未发生RD的眼睛相比，发生RD的眼睛在发病时眼压（IOP）较低(RD: 14.0±6.5 mm Hg vs.无RD；17.3±7.7 mm Hg, p = 0.02)，耐甲氧西林金黄色葡萄球菌（MRSA）血培养阳性率较高(RD: （13/30) 43.3% vs无RD: (9/63) 14.3%, p = 0.004）。与未发生RD的眼睛相比，发生RD的眼睛的玻璃体内注射次数更高（RD: 5.3±3.3 vs.未发生RD: 3.9±3.0,p = 0.02），而接受玻璃体切除术的眼睛的后续RD没有差异（p = 0.19）。在控制了年龄、性别和随访时间后，就诊时较低的IOP和MRSA阳性血培养与随后RD的发生率显著升高相关。结论：就诊时较低IOP和MRSA阳性血培养的眼睛与随后RD的发生率较高相关，即使在控制了年龄、性别和随访时间后也是如此。可能需要对伴有MRSA菌血症的EE患者进行更长时间的随访，并且需要更大规模的队列研究来确定与RD相关的其他特征。

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来源期刊

Ocular Immunology and Inflammation 医学-眼科学

CiteScore

6.20

自引率

15.20%

发文量

285

审稿时长

6-12 weeks

期刊介绍： Ocular Immunology & Inflammation ranks 18 out of 59 in the Ophthalmology Category.Ocular Immunology and Inflammation is a peer-reviewed, scientific publication that welcomes the submission of original, previously unpublished manuscripts directed to ophthalmologists and vision scientists. Published bimonthly, the journal provides an international medium for basic and clinical research reports on the ocular inflammatory response and its control by the immune system. The journal publishes original research papers, case reports, reviews, letters to the editor, meeting abstracts, and invited editorials.