The adult HNRNPH1::ERG positive acute myeloid leukemia with clear lower remission and worse prognosis: A case report and review of the literature.

IF 1.3 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Medicine Pub Date : 2025-04-04 DOI:10.1097/MD.0000000000041809

Yanyan Lu, Rui Wei, Jianlan Li, Lianrong Xu

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引用次数: 0

Abstract

Rationale: Acute myeloid leukemia (AML) derived from t(5;21)(q35;q22) translocation, post-transcriptional translation, forming the HNRNPH1::ERG fusion gene is a rare group of recurrent chromosomal abnormality myeloid malignancies. Only 1 adult case of AML has been reported so far. Here we identified a disparate adult case of HNRNPH1::ERG positive AML with clear breakpoint locations by utilizing The RNA sequencing(RNA-seq) and we addressed the clinical, treatment, pathological and molecular mechanism, along with a review of the literature.

Patients concerns: A 54-year-old man visited our department with fever and fatigue for 10 days.

Diagnoses: Diagnosed with acute myeloid leukemia (AML) through morphology, immunology, Cytogenetics, and Molecular biology (MICM) typing, with a confirmed HNRNPH1-ERG fusion gene.

Interventions: Multiple induction chemotherapy combined with targeted therapy was performed.

Outcomes: He died in February 2024.

Lessons: In our review, Only 1 adult case of AML has been reported so far. To summarize the 5 cases in the studies, the HNRNPH1::ERG positive AML cases had a significantly higher blast cell counts and more frequently companied with rare gene mutations, which characterized poorer prognosis and lower remission in adult HNRNPH1::ERG positive AML.

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来源期刊

Medicine 医学-医学：内科

CiteScore

2.80

自引率

0.00%

发文量

4342

审稿时长

>12 weeks

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