Evaluating Primitive Reflexes in Early Childhood as a Potential Biomarker for Developmental Disabilities.

IF 1.6 4区 医学 Q2 PEDIATRICS
Gerry Leisman, Robert Melillo
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引用次数: 0

Abstract

We aim to understand better the significance of retained primitive reflexes (RPRs) and examine the effect of RPRs in children, adolescents, and adults, focusing on autism spectrum disorder (ASD) and other neurodevelopmental conditions, as well as examine a basis for future treatment alternatives. We included a history section to better recognise the way that the scientific and medical communities have studied and understood the importance of RPRs. We review findings indicating that aspects of these disorders are related to the presence of functional disconnectivities related to a cortical maturational effect on neuronal networks. Cortical maturational delay within specific networks may lead to enhanced growth and maturation in other networks, resulting in asynchronous development and inconsistency in functional skills. There has been reported an overconnectivity of short-range, more immature connections and an underconnectivity of long-range, more mature connectivities. We review the relationship between motor and cognitive impairments and RPRs. A crucial conclusion will be that inhibiting these RPRs is representative of treatment targets.

评估儿童早期原始反射作为发育障碍的潜在生物标志物。
我们的目标是更好地了解保留原始反射(RPRs)的重要性,并研究RPRs在儿童、青少年和成人中的作用,重点关注自闭症谱系障碍(ASD)和其他神经发育疾病,并为未来的治疗选择提供基础。我们加入了一个历史部分,以便更好地认识到科学界和医学界研究和理解rpr重要性的方式。我们回顾了研究结果,表明这些疾病的各个方面都与神经网络皮层成熟效应相关的功能失联的存在有关。特定网络的皮层成熟延迟可能导致其他网络的生长和成熟增强,导致功能技能的异步发展和不一致。有报道称,近距离、更不成熟的连接过度连接,而远距离、更成熟的连接连接不足。本文综述了运动和认知障碍与RPRs之间的关系。一个关键的结论是,抑制这些RPRs是治疗目标的代表性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
2.90
自引率
5.90%
发文量
487
审稿时长
3-6 weeks
期刊介绍: The Journal of Paediatrics and Child Health publishes original research articles of scientific excellence in paediatrics and child health. Research Articles, Case Reports and Letters to the Editor are published, together with invited Reviews, Annotations, Editorial Comments and manuscripts of educational interest.
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