The effectiveness of mindfulness-based interventions on menopausal symptoms: A systematic review and meta-analysis of randomized controlled trials

IF 4.9 2区医学 Q1 CLINICAL NEUROLOGY

Journal of affective disorders Pub Date : 2025-04-05 DOI:10.1016/j.jad.2025.04.029

Hongjuan Wang , Hui Wang , Jojo Yan Yan Kwok , Siyuan Tang , Mei Sun

{"title":"The effectiveness of mindfulness-based interventions on menopausal symptoms: A systematic review and meta-analysis of randomized controlled trials","authors":"Hongjuan Wang , Hui Wang , Jojo Yan Yan Kwok , Siyuan Tang , Mei Sun","doi":"10.1016/j.jad.2025.04.029","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Menopause, a crucial transitioning stage for women, can significantly impact mood and wellbeing. We aimed to systematically examine the effectiveness of Mindfulness-based interventions (MBIs) on health outcomes, including menopausal symptoms, quality of life (QOL), sleep quality, anxiety, depressive symptoms, stress, mindfulness levels, and female sexual function index.</div></div><div><h3>Methods</h3><div>Eight databases were searched from inception to November 4, 2024 for randomized controlled trials. Two researchers independently selected, extracted, and appraised trials using the Cochrane Collaboration's ‘risk of bias’ tool. Meta-analysis, subgroup analysis, leave-one-out sensitivity analysis, and meta-regression were performed using Stata 18.0. The Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) was used to assess the quality of evidence.</div></div><div><h3>Results</h3><div>A total of 19 studies (1670 participants) published between 2011 and 2024 were identified. Of these, 18 studies were included in the meta-analysis. Compared with control group, The pooled analysis demonstrated that MBIs had statistically significant effects on menopausal symptoms (SMD, −2.10; 95 % CI, −3.49 to −0.70), QOL (SMD, −0.88; 95 % CI, −1.67 to −0.09), sleep quality (SMD, −0.92; 95 % CI, −1.65 to −0.20), anxiety (SMD, −1.03; 95 % CI, −1.42 to −0.66), depressive symptoms (SMD, −0.91; 95 % CI, −1.30 to −0.53), stress (SMD, −0.85; 95 % CI, −1.55 to −0.15), and mindfulness levels (SMD, 1.19; 95 % CI, 0.35 to 2.02). The overall quality of evidence for all pooled estimates were graded as low and moderate due to methodological limitations and small sample size. The low attrition rate (6 %) and relatively high adherence rate (79 %) highlight the acceptability of MBIs.</div></div><div><h3>Conclusions</h3><div>This systematic review and meta-analysis support using of MBIs to improve health outcomes in menopausal women. Rigorous randomized controlled trials with extended follow-up are needed to elucidate the mechanisms linking MBIs to menopausal health and strengthen evidence for clinical application.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"381 ","pages":"Pages 337-349"},"PeriodicalIF":4.9000,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of affective disorders","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0165032725005907","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Menopause, a crucial transitioning stage for women, can significantly impact mood and wellbeing. We aimed to systematically examine the effectiveness of Mindfulness-based interventions (MBIs) on health outcomes, including menopausal symptoms, quality of life (QOL), sleep quality, anxiety, depressive symptoms, stress, mindfulness levels, and female sexual function index.

Methods

Eight databases were searched from inception to November 4, 2024 for randomized controlled trials. Two researchers independently selected, extracted, and appraised trials using the Cochrane Collaboration's ‘risk of bias’ tool. Meta-analysis, subgroup analysis, leave-one-out sensitivity analysis, and meta-regression were performed using Stata 18.0. The Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) was used to assess the quality of evidence.

Results

A total of 19 studies (1670 participants) published between 2011 and 2024 were identified. Of these, 18 studies were included in the meta-analysis. Compared with control group, The pooled analysis demonstrated that MBIs had statistically significant effects on menopausal symptoms (SMD, −2.10; 95 % CI, −3.49 to −0.70), QOL (SMD, −0.88; 95 % CI, −1.67 to −0.09), sleep quality (SMD, −0.92; 95 % CI, −1.65 to −0.20), anxiety (SMD, −1.03; 95 % CI, −1.42 to −0.66), depressive symptoms (SMD, −0.91; 95 % CI, −1.30 to −0.53), stress (SMD, −0.85; 95 % CI, −1.55 to −0.15), and mindfulness levels (SMD, 1.19; 95 % CI, 0.35 to 2.02). The overall quality of evidence for all pooled estimates were graded as low and moderate due to methodological limitations and small sample size. The low attrition rate (6 %) and relatively high adherence rate (79 %) highlight the acceptability of MBIs.

Conclusions

This systematic review and meta-analysis support using of MBIs to improve health outcomes in menopausal women. Rigorous randomized controlled trials with extended follow-up are needed to elucidate the mechanisms linking MBIs to menopausal health and strengthen evidence for clinical application.

查看原文本刊更多论文

正念干预对更年期症状的有效性：随机对照试验的系统回顾和荟萃分析。

背景：更年期是女性重要的过渡阶段，会对情绪和健康产生重大影响。我们的目的是系统地检查正念干预（mbi）对健康结果的有效性，包括更年期症状、生活质量（QOL）、睡眠质量、焦虑、抑郁症状、压力、正念水平和女性性功能指数。方法：在8个数据库中检索自成立至2024年11月4日的随机对照试验。两位研究者使用Cochrane协作的“偏倚风险”工具独立选择、提取和评价试验。采用Stata 18.0进行meta分析、亚组分析、留一敏感性分析和meta回归分析。推荐、评估、发展和评价分级（GRADE）用于评估证据的质量。结果：2011年至2024年间共发表了19项研究（1670名参与者）。其中，18项研究被纳入meta分析。与对照组相比，合并分析显示mbi对绝经期症状有统计学意义(SMD, -2.10；95 % CI, -3.49 ~ -0.70)，生活质量(SMD, -0.88；95 % CI, -1.67 ~ -0.09)，睡眠质量(SMD, -0.92；95 % CI, -1.65至-0.20)，焦虑(SMD, -1.03；95 % CI, -1.42至-0.66)，抑郁症状(SMD, -0.91；95 % CI, -1.30至-0.53)，压力(SMD, -0.85；95 % CI, -1.55至-0.15)和正念水平(SMD, 1.19；95 % CI, 0.35 ~ 2.02)。由于方法学的限制和样本量小，所有汇总估计的总体证据质量被评为低和中等。低流失率（6 %）和相对较高的依从率（79 %）突出了MBIs的可接受性。结论：本系统综述和荟萃分析支持使用mbi改善绝经期妇女的健康结局。需要严格的随机对照试验和长期随访来阐明mbi与绝经期健康的联系机制，并加强临床应用的证据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of affective disorders 医学-精神病学

CiteScore

10.90

自引率

6.10%

发文量

1319

审稿时长

9.3 weeks

期刊介绍： The Journal of Affective Disorders publishes papers concerned with affective disorders in the widest sense: depression, mania, mood spectrum, emotions and personality, anxiety and stress. It is interdisciplinary and aims to bring together different approaches for a diverse readership. Top quality papers will be accepted dealing with any aspect of affective disorders, including neuroimaging, cognitive neurosciences, genetics, molecular biology, experimental and clinical neurosciences, pharmacology, neuroimmunoendocrinology, intervention and treatment trials.