Estimation of the number of people with Down syndrome living in Canada.

IF 6.6 1区医学 Q1 GENETICS & HEREDITY

Genetics in Medicine Pub Date : 2025-04-04 DOI:10.1016/j.gim.2025.101422

Gert de Graaf, Laura LaChance, Frank Buckley, Brian G Skotko

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引用次数: 0

Abstract

Purpose: We estimate the live births (LBs), selective terminations, miscarriages, and overall population with Down syndrome (DS) in Canada from 1950-2020. This study adds to previous work from the United States, Europe, Australia, and New Zealand.

Method: The LBs with DS-in the absence of DS-related terminations-were estimated on the maternal age distribution in the general population. Actual LBs were modeled on registry data. We applied constructed survival curves to annual LBs to estimate population numbers.

Results: In 2020, there were an estimated 418 LBs with DS in Canada. As a result of DS-related elective terminations, there were 54% fewer children with DS born than potentially could have been born in Canada, as of 2020. The estimated number of people with DS in Canada has increased from 5,138 people in 1950 to 22,367 in 2020.

Conclusion: Whereas, in recent years, the population size of people with DS is decreasing in Australia, New Zealand, and Europe, the number of people with DS is still growing in the United States and Canada. In Canada, however, the growth rate is increasingly slowing down, probably foreshadowing a population contraction in the coming years.

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估计居住在加拿大的唐氏综合症患者的数量。

目的：我们估计了1950-2020年加拿大唐氏综合征（DS）的活产（LBs）、选择性终止妊娠、流产和总体人口。这项研究是在美国、欧洲、澳大利亚和新西兰之前的研究基础上进行的。方法：根据一般人群中产妇年龄分布，对无ds相关终止妊娠的ds - lb进行估计。实际的LBs是根据注册表数据建模的。我们将构建的生存曲线应用于年度LBs来估计种群数量。结果：2020年，加拿大估计有418磅患有DS。截至2020年，由于与DS相关的选择性终止妊娠，加拿大出生的DS儿童比可能出生的儿童少54%。据估计，加拿大患有DS的人数已从1950年的5138人增加到2020年的22367人。结论：近年来，在澳大利亚、新西兰和欧洲，退行性痴呆的人口规模正在减少，而在美国和加拿大，退行性痴呆的人数仍在增长。然而，在加拿大，人口增长率正在逐渐放缓，这可能预示着未来几年的人口萎缩。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Genetics in Medicine 医学-遗传学

CiteScore

15.20

自引率

6.80%

发文量

857

审稿时长

1.3 weeks

期刊介绍： Genetics in Medicine (GIM) is the official journal of the American College of Medical Genetics and Genomics. The journal''s mission is to enhance the knowledge, understanding, and practice of medical genetics and genomics through publications in clinical and laboratory genetics and genomics, including ethical, legal, and social issues as well as public health. GIM encourages research that combats racism, includes diverse populations and is written by authors from diverse and underrepresented backgrounds.