Effects of high-flow oxygen therapy on oxygenation in dogs undergoing diagnostic bronchoscopy.

IF 2.6 2区农林科学 Q1 VETERINARY SCIENCES

Frontiers in Veterinary Science Pub Date : 2025-03-24 eCollection Date: 2025-01-01 DOI:10.3389/fvets.2025.1545427

Julia Ortlieb, Hannah Bender, Matthias Schneider, Sabine Tacke, Esther Hassdenteufel

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引用次数: 0

Abstract

Introduction: Hypoxemia is a common complication during bronchoscopy and bronchoalveolar lavage (BAL). High-Flow Oxygen Therapy (HFOT) has been used to improve oxygenation and prevent periods of hypoxemia in people undergoing bronchoscopy.

Objective: The main objective of this study was to evaluate the effect of HFOT on oxygenation in dogs undergoing diagnostic bronchoscopy compared to a traditional oxygen supplementation method (TOT). A secondary objective was to assess potential HFOT-related complications.

Methods: Prospective randomized clinical trial. Dogs presented for diagnostic bronchoscopy were randomly assigned to receive either HFOT or TOT using nasal cannulas during the bronchoscopic procedure. Oxygenation was monitored through PaO₂ measurements taken at seven time points: baseline (t0), after preoxygenation (t1), post-induction (t2), pre- and post-BAL sampling (t3 and t4), at the end of the procedure (t5), and 1 h after bronchoscopy (t6). Pre- and post-procedure thoracic radiographs were assessed for air leak syndrome or aerophagia.

Results: 20 privately owned dogs presented for diagnostic bronchoscopy were included in the study (HFOT group: n = 10, TOT group: n = 10). Baseline characteristics and physiological parameters did not differ significantly between groups. Five dogs in each group showed hypoxemia (PaO₂ < 80 mmHg) at baseline with 1/5 in each group having PaO₂ < 60 mmHg. HFOT improved oxygenation throughout the procedure, with a significant increase in PaO₂ observed after preoxygenation (P = 0.001) and at the end of the procedure (P = 0.013). Additionally, only 1/10 dogs in the HFOT group experienced hypoxemia during bronchoscopy compared to 5/10 dogs in the TOT group, and patients in the HFOT achieved numerically higher PaO₂ values across all time points during the procedure (t1-t5). No serious adverse events related to HFOT were observed, although aerophagia occurred in both groups without necessitating intervention.

Conclusion: HFOT can improve oxygenation and prevent episodes of hypoxemia in dogs undergoing bronchoscopy compared to traditional oxygen supplementation methods.

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高流量氧治疗对诊断性支气管镜检查犬氧合的影响。

低氧血症是支气管镜检查和支气管肺泡灌洗术（BAL）的常见并发症。高流量氧疗（HFOT）已被用于改善氧合和预防支气管镜检查患者的低氧血症。目的：本研究的主要目的是评估HFOT对诊断性支气管镜检查犬氧合的影响，并与传统的补氧方法（TOT）进行比较。次要目的是评估潜在的hft相关并发症。方法：前瞻性随机临床试验。在支气管镜检查过程中，接受诊断性支气管镜检查的狗被随机分配接受HFOT或使用鼻插管的TOT。通过在七个时间点测量PaO2来监测氧合：基线（t0）、预充氧后（t1）、诱导后（t2）、bal取样前和后（t3和t4）、手术结束时（t5）和支气管镜检查后1小时（t6）。术前和术后胸片评估是否有漏气综合征或食气症。结果：20只接受支气管镜诊断的私人犬被纳入研究（HFOT组：n = 10， TOT组：n = 10）。各组间基线特征和生理参数无显著差异。每组5只狗在基线时出现低氧血症（PaO2 < 80 mmHg），每组1/5狗PaO2 < 60 mmHg。HFOT改善了整个手术过程中的氧合，在预充氧后和手术结束时观察到PaO2显著增加（P = 0.001）。此外，HFOT组中只有1/10的狗在支气管镜检查期间出现低氧血症，而TOT组为5/10，HFOT患者在手术过程中所有时间点的PaO2值都较高（t1-t5）。没有观察到与HFOT相关的严重不良事件，尽管两组患者在没有必要干预的情况下都发生了噬气症。结论：与传统的补氧方法相比，HFOT可以改善支气管镜检查犬的氧合，预防低氧血症的发生。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Veterinary Science Veterinary-General Veterinary

CiteScore

4.80

自引率

9.40%

发文量

1870

审稿时长

14 weeks

期刊介绍： Frontiers in Veterinary Science is a global, peer-reviewed, Open Access journal that bridges animal and human health, brings a comparative approach to medical and surgical challenges, and advances innovative biotechnology and therapy. Veterinary research today is interdisciplinary, collaborative, and socially relevant, transforming how we understand and investigate animal health and disease. Fundamental research in emerging infectious diseases, predictive genomics, stem cell therapy, and translational modelling is grounded within the integrative social context of public and environmental health, wildlife conservation, novel biomarkers, societal well-being, and cutting-edge clinical practice and specialization. Frontiers in Veterinary Science brings a 21st-century approach—networked, collaborative, and Open Access—to communicate this progress and innovation to both the specialist and to the wider audience of readers in the field. Frontiers in Veterinary Science publishes articles on outstanding discoveries across a wide spectrum of translational, foundational, and clinical research. The journal''s mission is to bring all relevant veterinary sciences together on a single platform with the goal of improving animal and human health.