Correlation study of facial lipid profile differences and skin physiological characteristics in Chinese women aged 19–33 years

IF 2.5 4区医学 Q2 DERMATOLOGY

International Journal of Cosmetic Science Pub Date : 2025-04-07 DOI:10.1111/ics.13065

Yumei Fan, Chunhua Wei, Ning Su, Yanyun Ma, Wei Liu, Peiwen Sun, Shuo Shan

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Abstract

Background

Changes in the stratum corneum (SC) lipid profiles are associated with various skin diseases. Factors, including age, ethnicity, season and anatomical location, can influence the variations in SC lipid profiles. According to reports, the facial sebum of Chinese women peaks at age 20–30, accompanied by various signs of facial ageing. No studies have investigated how facial SC lipid profiles change with age in young Chinese women.

Objectives

This study aimed to observe the differences in the facial SC lipid profiles of Chinese female volunteers aged 19–33 and determined the relationship between key lipids and physiological parameters.

Methods

Differential lipids were detected and screened in healthy Chinese women aged 19–33 through ultra-performance liquid chromatography–mass spectrometry. The relationship between these lipids and the skin's physiological parameters was determined.

Results

The facial SC lipid profiles of young Chinese women exhibited significant differences with age. The results indicated that 40 lipids increased with age, while 51 types decreased. The average chain length of diglycerides (DG), triglycerides (TG) and short-chain ceramides decreased with age, while cholesterol esters (CE) and ceramides {Cer, Cer/EODS (d19:0/18:1/O/16:0) and Cer/EOS (d28:1/12:0/O/14:0)} increased with age.

Cer/EODS (d19:0/18:1/O/16:0), Cer/EOS (d28:1/12:0/O/14:0) and HexCer/NDS (d14:0/33:1) were positively correlated with trans-epidermal water loss, skin elasticity and skin brightness, while Cer/AP (t18:0/20:0) was negatively correlated with skin elasticity. This study comprehensively explains the differences in lipid profile composition and skin ageing in young populations.

Conclusions

Young Chinese women's facial skin SC lipid profiles significantly change with age. Age-related changes result in variations in DG and CE levels and changes in the chain lengths of TG and Cer. Age-related changes in Cer content affect skin barrier function, elasticity and brightness.

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中国19-33岁女性面部脂质谱差异与皮肤生理特征的相关性研究

背景：角质层（SC）脂质谱的变化与多种皮肤病有关。年龄、种族、季节和解剖位置等因素可影响SC脂质谱的变化。据报道，中国女性的面部皮脂在20-30岁达到峰值，伴随着各种面部衰老迹象。目前还没有研究调查中国年轻女性面部SC脂质谱随年龄的变化。目的：本研究旨在观察19-33岁中国女性志愿者面部SC脂质谱的差异，并确定关键脂质与生理参数的关系。方法：采用超高效液相色谱-质谱联用技术对19 ~ 33岁的中国健康女性进行差异脂质检测和筛选。确定了这些脂质与皮肤生理参数之间的关系。结果：中国年轻女性面部SC脂质谱随年龄有显著差异。结果表明，有40种脂质随年龄增长而增加，51种脂质随年龄增长而减少。甘油三酯（DG）、甘油三酯（TG）和短链神经酰胺的平均链长随着年龄的增长而减少，而胆固醇酯（CE）和神经酰胺{Cer、Cer/EODS （d19:0/18:1/O/16:0）和Cer/EOS (d28:1/12:0/O/14:0)}的平均链长随着年龄的增长而增加。Cer/EODS （d19:0/18:1/O/16:0）、Cer/EOS （d28:1/12:0/O/14:0）和HexCer/NDS （d14:0/33:1）与表皮水分流失、皮肤弹性和皮肤亮度呈正相关，而Cer/AP （t18:0/20:0）与皮肤弹性呈负相关。这项研究全面解释了年轻人群中脂质剖面组成和皮肤老化的差异。结论：中国年轻女性面部皮肤SC脂质谱随年龄变化显著。年龄相关的变化导致DG和CE水平的变化以及TG和Cer链长度的变化。年龄相关的Cer含量变化会影响皮肤的屏障功能、弹性和亮度。

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来源期刊

International Journal of Cosmetic Science DERMATOLOGY-

CiteScore

4.60

自引率

4.30%

发文量

期刊介绍： The Journal publishes original refereed papers, review papers and correspondence in the fields of cosmetic research. It is read by practising cosmetic scientists and dermatologists, as well as specialists in more diverse disciplines that are developing new products which contact the skin, hair, nails or mucous membranes. The aim of the Journal is to present current scientific research, both pure and applied, in: cosmetics, toiletries, perfumery and allied fields. Areas that are of particular interest include: studies in skin physiology and interactions with cosmetic ingredients, innovation in claim substantiation methods (in silico, in vitro, ex vivo, in vivo), human and in vitro safety testing of cosmetic ingredients and products, physical chemistry and technology of emulsion and dispersed systems, theory and application of surfactants, new developments in olfactive research, aerosol technology and selected aspects of analytical chemistry.