{"title":"Effects of Diacylglycerol Oil on Overweight or Obese Patients with Diabetes or Prediabetes: a Single-Arm Trial.","authors":"Biying Zhong, Yining Ding, Bingxin Wu, Guiyu Li, Jinhai Lin, Luoqi Lin, Miaoyang Lin, Zhiwei Huang, Yonghua Wang, Danping Xu","doi":"10.2147/DMSO.S491740","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>The annual incidence of overweight or obesity and abnormally elevated blood glucose levels in China is increasing. According to research, diacylglycerol oil offers effective lipid-lowering and weight-loss properties. This study aimed to elucidate the effects of diacylglycerol oil on overweight and obese patients with unusually high blood glucose levels.</p><p><strong>Methods: </strong>This is a single-arm trial. A total of 75 overweight or obese subjects with abnormally elevated blood glucose levels were included in this study. Subjects were requested to use diacylglycerol oil to cook food daily for two months and to maintain their daily eating habits and drug treatment regimen. Study-related parameters were assessed, respectively, during the screening period, one month, and two months following DAG oil consumed.</p><p><strong>Results: </strong>Fasting blood glucose (FBG), body weight, body mass index (BMI), waist circumference, and hip circumference decreased compared with baseline after consuming diacylglycerol oil for two months. FBG and glycosylated hemoglobin (HbAlc) levels decreased in prediabetic subjects (FBG decreased at visit 2 months: -0.31 mmol/l; at visit 1 month: -0.28 mmol/l; HbAlc decreased at visit 2: -0.10%; <i>P</i> < 0.05), but there were no significant difference changes in diabetic subjects. In diabetic participants, triglyceride (TAG) levels reduced by 0.17 mmol/l, whereas in prediabetic subjects, total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels decreased by 0.27 mmol/l and 0.28 mmol/l, respectively (<i>P</i> < 0.05). There were no significant differences in the changes in high-density lipoprotein cholesterol (HDL-C) and uric acid (UA) between two groups. Compared to baseline, diabetic participants' body weight, BMI, and waist-to-hip ratio (WHR) dropped by 0.54 kg, 0.20, and 0.01 kg, respectively (P < 0.05). And prediabetic participants' BMI, waist circumference, and hip circumference dropped by 0.43, 1.43, and 1.53 cm, respectively (P < 0.05).</p><p><strong>Conclusion: </strong>Diacylglycerol oil may help to prevent diabetes and delays its progression in overweight or obese patients.</p><p><strong>Clinical trial registry: </strong>ChiCTR2000028888 at www.chictr.org.cn.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"18 ","pages":"1015-1024"},"PeriodicalIF":2.8000,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11974550/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2147/DMSO.S491740","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
引用次数: 0
Abstract
Objective: The annual incidence of overweight or obesity and abnormally elevated blood glucose levels in China is increasing. According to research, diacylglycerol oil offers effective lipid-lowering and weight-loss properties. This study aimed to elucidate the effects of diacylglycerol oil on overweight and obese patients with unusually high blood glucose levels.
Methods: This is a single-arm trial. A total of 75 overweight or obese subjects with abnormally elevated blood glucose levels were included in this study. Subjects were requested to use diacylglycerol oil to cook food daily for two months and to maintain their daily eating habits and drug treatment regimen. Study-related parameters were assessed, respectively, during the screening period, one month, and two months following DAG oil consumed.
Results: Fasting blood glucose (FBG), body weight, body mass index (BMI), waist circumference, and hip circumference decreased compared with baseline after consuming diacylglycerol oil for two months. FBG and glycosylated hemoglobin (HbAlc) levels decreased in prediabetic subjects (FBG decreased at visit 2 months: -0.31 mmol/l; at visit 1 month: -0.28 mmol/l; HbAlc decreased at visit 2: -0.10%; P < 0.05), but there were no significant difference changes in diabetic subjects. In diabetic participants, triglyceride (TAG) levels reduced by 0.17 mmol/l, whereas in prediabetic subjects, total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels decreased by 0.27 mmol/l and 0.28 mmol/l, respectively (P < 0.05). There were no significant differences in the changes in high-density lipoprotein cholesterol (HDL-C) and uric acid (UA) between two groups. Compared to baseline, diabetic participants' body weight, BMI, and waist-to-hip ratio (WHR) dropped by 0.54 kg, 0.20, and 0.01 kg, respectively (P < 0.05). And prediabetic participants' BMI, waist circumference, and hip circumference dropped by 0.43, 1.43, and 1.53 cm, respectively (P < 0.05).
Conclusion: Diacylglycerol oil may help to prevent diabetes and delays its progression in overweight or obese patients.
Clinical trial registry: ChiCTR2000028888 at www.chictr.org.cn.
期刊介绍：
An international, peer-reviewed, open access, online journal. The journal is committed to the rapid publication of the latest laboratory and clinical findings in the fields of diabetes, metabolic syndrome and obesity research. Original research, review, case reports, hypothesis formation, expert opinion and commentaries are all considered for publication.
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