Obsessive-compulsive disorder and temporal lobe porencephaly: a case report.

IF 3.4 2区医学 Q2 PSYCHIATRY

BMC Psychiatry Pub Date : 2025-04-07 DOI:10.1186/s12888-025-06774-8

Gaoju Deng, Yuan Cao, Changjian Qiu

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Abstract

Background: The functional and structural abnormalities of cortico-striato-thalamo-cortex have been reported to be associated with the neurobiological basis of obsessive-compulsive disorder (OCD). OCD can also occur in the striatum damaging after brain infarction, which is called OCD caused by physical diseases. The relationship and mechanism between temporal lobe abnormalities and OCD are still unclear.

Case presentation: A young male with temporal lobe porencephaly presented with obsessive-compulsive symptoms. The cognition of this OCD participant was not significantly impaired, and his social function was well maintained. After treatment with sertraline, aripiprazole, and fluvoxamine, he was improved but relapsed several times after drug withdrawal. However, the therapeutic effect was sustained upon reinitiation of the medication.

Conclusion: This is the first reported case of OCD in an individual with left temporal lobe porencephaly. The possible relationship between obsessive-compulsive symptoms and temporal lobe structural abnormalities needs to be further studied. The maintenance treatment and prognosis of organic obsessive-compulsive disorder also deserve further study.

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强迫症合并颞叶裂孔畸形1例。

背景：皮质-纹状体-丘脑皮层的功能和结构异常与强迫症（OCD）的神经生物学基础有关。强迫症也可发生在脑梗死后纹状体损伤部位，称为躯体疾病引起的强迫症。颞叶异常与强迫症之间的关系和机制尚不清楚。病例介绍：一位年轻男性颞叶颅孔畸形表现为强迫症症状。该强迫症患者的认知能力未受明显损害，社交功能维持良好。经舍曲林、阿立哌唑、氟伏沙明治疗，病情有所好转，但停药后多次复发。然而，治疗效果持续在重新开始的药物治疗。结论：这是第一例报道的强迫症在个体左颞叶脑孔畸形。强迫症症状与颞叶结构异常之间的可能关系有待进一步研究。器质性强迫症的维持治疗及预后也值得进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Psychiatry 医学-精神病学

CiteScore

5.90

自引率

4.50%

发文量

716

审稿时长

3-6 weeks

期刊介绍： BMC Psychiatry is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of psychiatric disorders, as well as related molecular genetics, pathophysiology, and epidemiology.