Electroacupuncture's Impact on the Hippocampal RAGE/LRP1 Receptor System in SAMP8 Mice.

IF 3.2 3区生物学 Q3 MATERIALS SCIENCE, BIOMATERIALS

Advanced biology Pub Date : 2025-04-08 DOI:10.1002/adbi.202400377

Zhitao Hou, Jindi Ma, Xian Zhang, Liying Song, Yan Li, Xiaochen Song, Xinying Hu, Dongdong Li, Changyuan He, Yuefeng Sun, Hongbo Cai, Jing Chen

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引用次数: 0

Abstract

Age-related cognitive impairment (ARCI) is linked to β-amyloid (Aβ) accumulation and disrupted blood-brain barrier (BBB) transport via receptors for advanced glycation end products (RAGE) and low-density lipoprotein receptor-related protein 1 (LRP1). This study examines electroacupuncture (EA) effects on cognition, hippocampal pathology, neurotransmitters, and the RAGE/LRP1 system in senescence-accelerated mouse prone 8 (SAMP8) mice. EA at Zusanli (ST36) and Baihui (GV20) improved cognitive performance, reduced hippocampal neuronal degeneration, elevated cerebrospinal fluid dopamine, norepinephrine, serotonin, and 5-hydroxyindoleacetic acid, and decreased Aβ42 levels. EA downregulated hippocampal RAGE, vascular cell adhesion molecule-1 (VCAM-1), and intercellular adhesion molecule-1 (ICAM-1), upregulated LRP1 and apolipoprotein E (ApoE), promoting Aβ clearance. NF-κB expression remained unchanged, suggesting alternative anti-inflammatory pathways. Thus, EA offers a promising non-pharmacological treatment for ARCI.

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电针对SAMP8小鼠海马RAGE/LRP1受体系统的影响

年龄相关性认知障碍（ARCI）与β-淀粉样蛋白（Aβ）积累和通过晚期糖基化终产物（RAGE）受体和低密度脂蛋白受体相关蛋白1 （LRP1）的血脑屏障（BBB）运输中断有关。本研究探讨了电针（EA）对衰老加速小鼠（SAMP8）认知、海马病理、神经递质和RAGE/LRP1系统的影响。足三里（ST36）和百会（GV20） EA可改善认知能力，减少海马神经元变性，提高脑脊液多巴胺、去甲肾上腺素、血清素和5-羟吲哚乙酸水平，降低Aβ42水平。EA下调海马RAGE、血管细胞粘附分子-1 （VCAM-1）和细胞间粘附分子-1 (ICAM-1)，上调LRP1和载脂蛋白E (ApoE)，促进Aβ清除。NF-κB表达保持不变，提示有其他抗炎途径。因此，EA为ARCI提供了一种很有前景的非药物治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advanced biology Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)

CiteScore

6.60

自引率

0.00%

发文量

130