Enantioselective construction of functionalized oxazoles via anionic stereogenic-at-cobalt(iii) complex-catalyzed Ugi-4CR/Wittig reaction sequences†

IF 2.7 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2025-03-24 DOI:10.1039/d5ob00293a

Qi-Ming Wang , Chang-Min Peng , Yong-En Sun , Chuan-Zhi Yao , Hua-Jie Jiang , Jie Yu

引用次数: 0

Abstract

A one-pot synthesis of chiral multifunctional oxazole frameworks is accomplished via a cascade reaction involving an anionic stereogenic cobalt(iii) complex-catalyzed enantioselective Ugi four-component/Wittig process. This approach tolerates a complex reaction system that includes aldehydes, amines, carboxylic acids, and isocyano-(triphenylphosphoranylidene)acetates, yielding chiral 2,4,5-trisubstituted oxazoles with good enantioselectivities (up to 93 : 7 er).

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阴离子立体钴络合物催化Ugi-4CR/Wittig反应序列对映选择性构建功能化恶唑。

通过阴离子立体钴（III）络合物催化对映选择性Ugi四组分/Wittig工艺的级联反应，一锅法合成了手性多功能恶唑框架。该方法可耐受包括醛、胺、羧酸和异氰基（三苯基磷酰）醋酸酯在内的复杂反应体系，生成具有良好对映选择性的手性2,4,5-三取代恶唑（高达93:7 er）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.