Ultrasound-Induced Synchronized Neural Activities at 40 Hz and 200 Hz Entrained Corresponded Oscillations and Improve Alzheimer's Disease Memory

IF 4.8 1区医学 Q1 NEUROSCIENCES

CNS Neuroscience & Therapeutics Pub Date : 2025-04-09 DOI:10.1111/cns.70351

Jiamin Chen, Xingran Wang, Xin Li, Xiaoli Li, Yiyao Zhang, Yi Yuan

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Abstract

Aims

Neurological diseases like Alzheimer's disease (AD) with cognitive deficits show impaired theta, gamma, and ripple bands. Restoring these oscillations may be crucial for rescuing cognitive functions. Low-intensity transcranial ultrasound stimulation (TUS), a noninvasive neuromodulation method, offers high spatial resolution and deep penetration. However, it remains unclear how 40 Hz and 200 Hz TUS may improve memory in AD by regulating hippocampal oscillations.

Methods

We applied 40 Hz and 200 Hz TUS to the CA1 region of AD mice, performing memory assessments and CA1 electrophysiology recordings simultaneously.

Results

Our results showed that both 40 Hz and 200 Hz TUS significantly improved memory performance in AD mice by targeting the dorsal hippocampus and increasing power in corresponding frequency bands. Specifically, 40 Hz TUS enhanced gamma and ripple bands, while 200 Hz TUS strongly affected both. This enhancement increased during stimulation and persisted 5 days poststimulation. Improved coupling between theta and gamma oscillations indicated better hippocampal coordination with other brain regions. Additionally, 40 Hz TUS raised sharp wave ripple (SPW-Rs) incidence, and 200 Hz TUS increased both SPW-R incidence and duration, contributing to memory improvement. Behavioral performance significantly improved with TUS at both frequencies.

Conclusion

Ultrasound-induced synchronized neural activities at 40 Hz and 200 Hz entrained corresponding oscillations and improved memory in Alzheimer's disease.

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超声诱导的同步神经活动在40赫兹和200赫兹携带相应的振荡和改善阿尔茨海默病的记忆

神经系统疾病，如阿尔茨海默病（AD）与认知缺陷显示受损的θ， γ和纹波带。恢复这些振荡可能对拯救认知功能至关重要。低强度经颅超声刺激（TUS）是一种无创的神经调节方法，具有高空间分辨率和深度穿透性。然而，目前尚不清楚40赫兹和200赫兹的电流如何通过调节海马振荡来改善阿尔茨海默氏症患者的记忆。方法对AD小鼠CA1区施加40 Hz和200 Hz的TUS，同时进行记忆评估和CA1电生理记录。结果我们的研究结果表明，40 Hz和200 Hz的TUS通过靶向海马背侧并增加相应频段的功率，显著改善了AD小鼠的记忆性能。具体来说，40 Hz的TUS增强了伽马和纹波带，而200 Hz的TUS强烈影响两者。这种增强在刺激期间增强，并在刺激后持续5天。θ和γ振荡之间的耦合改善表明海马与大脑其他区域的协调更好。此外，40 Hz TUS增加了尖锐波纹波（SPW-Rs）的发生率，200 Hz TUS增加了SPW-R的发生率和持续时间，有助于改善记忆。两种频率的TUS均显著改善了行为表现。结论超声诱导的40 Hz和200 Hz同步神经活动具有相应的振荡，可改善阿尔茨海默病患者的记忆。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

CNS Neuroscience & Therapeutics 医学-神经科学

CiteScore

7.30

自引率

12.70%

发文量

240

审稿时长

2 months

期刊介绍： CNS Neuroscience & Therapeutics provides a medium for rapid publication of original clinical, experimental, and translational research papers, timely reviews and reports of novel findings of therapeutic relevance to the central nervous system, as well as papers related to clinical pharmacology, drug development and novel methodologies for drug evaluation. The journal focuses on neurological and psychiatric diseases such as stroke, Parkinson’s disease, Alzheimer’s disease, depression, schizophrenia, epilepsy, and drug abuse.