{"title":"Somatosensory Evoked Potential N20 as a Prognostic Tool for Upper Limb Function in Stroke Patients: A Focus on Basal Ganglia and Thalamus","authors":"Shuai Yang, Chin-hsuan Chia, Pei-pei Xu, Ya Zong, Weiming Zhang, Xiao-pei Sun, Jing-yun Xu, Qing Xie","doi":"10.1155/ane/2060433","DOIUrl":null,"url":null,"abstract":"<p><b>Objective:</b> This study is aimed at elucidating the prognostic utility of somatosensory evoked potentials (SEPs) N20 in the recovery of upper limb functionality among stroke patients with varying cerebral lesions.</p><p><b>Methods:</b> A cohort of 60 stroke patients enrolled in this study and stratified into two groups: 30 patients with strokes affecting the basal ganglia and 30 with thalamic involvement. Each patient underwent an SEP test after admission and participated in rehabilitation training for 3 months. Assessments were carried out using the Fugl–Meyer Assessment for Upper Extremity (FMA-UE), the Modified Ashworth Scale (MAS), and the Modified Barthel Index (MBI) at admission and 3 months after treatment to analyze the correlation between SEP-N20 indices and the function assessment scales in the two groups.</p><p><b>Results:</b> (1) SEP in stroke patients revealed notable abnormalities, in which a more pronounced reduction of the amplitude ratio of the N20 (SEPAR-N20) wave between the affected and unaffected sides was observed in the thalamus group (<i>p</i> < 0.05). (2) After 3 months, a significant positive correlation was established between the improvement rate of FMA-UE scores and SEPAR-N20 in the basal ganglia group (<i>r</i> = 0.696, <i>p</i> < 0.0001). Conversely, this correlation was not evident within the thalamus group (<i>r</i> = −0.157, <i>p</i> > 0.05). (3) There was no significant correlation between MAS or MBI scores and SEPAR-N20 in either group (<i>p</i> > 0.05).</p><p><b>Conclusion:</b> The extent of SEP abnormality poststroke is associated with the location of the lesion. Strokes involving the thalamus exhibited more pronounced changes in the N20 component. SEPAR-N20 might serve as a valuable predictor for the recovery of upper limb functionality, particularly in cases of basal ganglia strokes.</p><p><b>Trial Registration:</b> Chinese Clinical Trial Registry: ChiCTR2300075570</p>","PeriodicalId":6939,"journal":{"name":"Acta Neurologica Scandinavica","volume":"2025 1","pages":""},"PeriodicalIF":2.9000,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ane/2060433","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta Neurologica Scandinavica","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1155/ane/2060433","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
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Abstract
Objective: This study is aimed at elucidating the prognostic utility of somatosensory evoked potentials (SEPs) N20 in the recovery of upper limb functionality among stroke patients with varying cerebral lesions.
Methods: A cohort of 60 stroke patients enrolled in this study and stratified into two groups: 30 patients with strokes affecting the basal ganglia and 30 with thalamic involvement. Each patient underwent an SEP test after admission and participated in rehabilitation training for 3 months. Assessments were carried out using the Fugl–Meyer Assessment for Upper Extremity (FMA-UE), the Modified Ashworth Scale (MAS), and the Modified Barthel Index (MBI) at admission and 3 months after treatment to analyze the correlation between SEP-N20 indices and the function assessment scales in the two groups.
Results: (1) SEP in stroke patients revealed notable abnormalities, in which a more pronounced reduction of the amplitude ratio of the N20 (SEPAR-N20) wave between the affected and unaffected sides was observed in the thalamus group (p < 0.05). (2) After 3 months, a significant positive correlation was established between the improvement rate of FMA-UE scores and SEPAR-N20 in the basal ganglia group (r = 0.696, p < 0.0001). Conversely, this correlation was not evident within the thalamus group (r = −0.157, p > 0.05). (3) There was no significant correlation between MAS or MBI scores and SEPAR-N20 in either group (p > 0.05).
Conclusion: The extent of SEP abnormality poststroke is associated with the location of the lesion. Strokes involving the thalamus exhibited more pronounced changes in the N20 component. SEPAR-N20 might serve as a valuable predictor for the recovery of upper limb functionality, particularly in cases of basal ganglia strokes.
Trial Registration: Chinese Clinical Trial Registry: ChiCTR2300075570
期刊介绍：
Acta Neurologica Scandinavica aims to publish manuscripts of a high scientific quality representing original clinical, diagnostic or experimental work in neuroscience. The journal''s scope is to act as an international forum for the dissemination of information advancing the science or practice of this subject area. Papers in English will be welcomed, especially those which bring new knowledge and observations from the application of therapies or techniques in the combating of a broad spectrum of neurological disease and neurodegenerative disorders. Relevant articles on the basic neurosciences will be published where they extend present understanding of such disorders. Priority will be given to review of topical subjects. Papers requiring rapid publication because of their significance and timeliness will be included as ''Clinical commentaries'' not exceeding two printed pages, as will ''Clinical commentaries'' of sufficient general interest. Debate within the speciality is encouraged in the form of ''Letters to the editor''. All submitted manuscripts falling within the overall scope of the journal will be assessed by suitably qualified referees.
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