Research Progress on the Extraction, Structure Elucidation, Biological Activities, and Drug Carrier Applications of Polygonati Rhizom Polysaccharides

IF 3.5 2区农林科学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Food Biochemistry Pub Date : 2025-04-08 DOI:10.1155/jfbc/5515295

Qiangbao Xu, Qiuyue Lv, Zhu Yang, Yingying Zhang, Hui Che, Guodong Wang, Jun Han, Jiangping Wu

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Abstract

As widely used in traditional Chinese medicine and nutritional food, Polygonati Rhizom is known for its diverse pharmacological properties, including hematopoiesis, immune enhancement, antitumor, anti-inflammatory, antioxidant, antiaging, antiviral, and hepatoprotection. Polygonati Rhizom polysaccharides (PRPs) are primary bioactive compounds that are water-soluble and mainly comprise fructose (Fru), glucose (Glc), galactose (Gal), arabinose (Ara), rhamnose (Rha), fucose (Fuc), xylose (Xyl), glucuronic acid (GlcA), and galacturonic acid (GalA). Meanwhile, different extraction methods, such as hot water and ultrasonic extractions, can significantly affect the yield of PRPs, Additionally, PRPs were also reported to hold promising potential as a drug carrier. Herein, the extraction, structure elucidation, biological activities, and drug carrier applications of PRPs are systematically summarized, providing reference for the further research and development of Polygonati Rhizom.

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黄精根多糖的提取、结构解析、生物活性及药物载体应用研究进展

何首乌被广泛应用于传统中药和营养食品中，具有造血、增强免疫力、抗肿瘤、抗炎、抗氧化、抗衰老、抗病毒和保肝等多种药理作用。何首乌多糖（PRPs）是主要的生物活性化合物，具有水溶性，主要由果糖（Fru）、葡萄糖（Glc）、半乳糖（Gal）、阿拉伯糖（Ara）、鼠李糖（Rha）、岩藻糖（Fuc）、木糖（Xyl）、葡萄糖醛酸（GlcA）和半乳糖醛酸（GalA）组成。同时，不同的提取方法（如热水提取和超声波提取）会显著影响 PRPs 的产量。本文系统地总结了PRPs的提取、结构阐明、生物活性和药物载体应用，为进一步研究和开发黄精提供参考。

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来源期刊

Journal of Food Biochemistry 生物-生化与分子生物学

CiteScore

7.80

自引率

5.00%

发文量

488

审稿时长

3.6 months

期刊介绍： The Journal of Food Biochemistry publishes fully peer-reviewed original research and review papers on the effects of handling, storage, and processing on the biochemical aspects of food tissues, systems, and bioactive compounds in the diet. Researchers in food science, food technology, biochemistry, and nutrition, particularly based in academia and industry, will find much of great use and interest in the journal. Coverage includes: -Biochemistry of postharvest/postmortem and processing problems -Enzyme chemistry and technology -Membrane biology and chemistry -Cell biology -Biophysics -Genetic expression -Pharmacological properties of food ingredients with an emphasis on the content of bioactive ingredients in foods Examples of topics covered in recently-published papers on two topics of current wide interest, nutraceuticals/functional foods and postharvest/postmortem, include the following: -Bioactive compounds found in foods, such as chocolate and herbs, as they affect serum cholesterol, diabetes, hypertension, and heart disease -The mechanism of the ripening process in fruit -The biogenesis of flavor precursors in meat -How biochemical changes in farm-raised fish are affecting processing and edible quality