Synthesis and Characterization of Fe3O4@L-Arginine Magnetic Nanocatalyst Immobilized on Nickel Oxide for One-Pot Ultrasound-Assisted Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones

Abstract

In this work, we synthesized a heterogeneous magnetic nanocatalyst using iron oxide (Fe₃O₄) surface-modified with L-arginine@NiO (Fe₃O₄@L-Arg@NiO). Several characterization techniques such as fourier transform infrared (FT-IR), field emission scanning electron microscopy (FE-SEM), X-ray diffraction (XRD), high-resolution transmission electron microscopy (HR-TEM), electron dispersion spectra (EDS) and thermogravimetric analysis (TGA) were used to extensively analyze its structural and morphological properties. The Fe₃O₄@L-Arg@NiO nanocatalyst was subjected to the one-pot multi-component synthesis of 3,4-dihydropyrimidin-2-(1H)-ones derivatives under solvent-free conditions. It was determined that nanocatalyst Fe₃O₄@L-Arg@NiO demonstrating desired product 3,4-dihydropyrimidin-2-(1H)-ones with 85%–95% yield, in shorter reaction time. Furthermore, simple work-up, reusability of the catalyst up to five cycles and sustainability of the catalyst are characteristic features of this environment friendly protocol.