Association Between Ankle-Brachial Index and Risk of Early Neurological Deterioration After Acute Isolated Pontine Infarction

IF 2.6 3区心理学 Q2 BEHAVIORAL SCIENCES

Brain and Behavior Pub Date : 2025-04-09 DOI:10.1002/brb3.70481

Dong-Bo Liu, Bing-Xian Zhang, Yao Zhou, Jian-Hua Zhao, Jie-Wen Zhang

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Abstract

Introduction

Lower ankle-brachial index (ABI) has been linked to worse prognosis after ischemic stroke, including greater risk of recurrence. Whether the index also correlates with risk of early neurological deterioration after acute cerebral infarction is unclear.

Material and methods

We prospectively analyzed patients admitted to our hospital between February 2019 and January 2024 for acute isolated pontine infarction and who showed an ABI no greater than 1.40. Patients were classified into three groups according to whether their index was low (≤0.90), borderline (0.91–1.10), or normal (1.11–1.40). We compared the index between patients who showed early neurological deterioration or not, which was defined as an increase of at least one point on the motor item on the National Institute of Health Stroke Scale (NIHSS) or at least two points on the total NIHSS score during the first week after admission.

Results:

Of the 408 patients in our analysis, 120 (29.4%) showed early neurological deterioration. ABI showed the following distribution: low, 108 patients (26.5%); borderline, 136 (33.3%); and normal, 164 (40.2%). In multivariate regression, borderline values of ABI (0.91–1.10) were associated with significantly lower risk of early neurological deterioration (OR 0.457, 95% CI: 0.246–0.848), whereas low values (≤0.90) were associated with significantly higher risk (OR 1.975, 95% CI: 1.110–3.512).

Conclusions:

Low ABI may independently predict increased risk of early neurological deterioration following acute isolated pontine infarction. Borderline ABI, in contrast, may independently predict reduced risk.

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踝臂指数与急性孤立性桥脑梗死后早期神经功能恶化风险的关系

较低的踝肱指数（ABI）与缺血性卒中后较差的预后有关，包括较高的复发风险。该指数是否也与急性脑梗死后早期神经功能恶化的风险相关尚不清楚。材料与方法前瞻性分析2019年2月至2024年1月我院收治的急性孤立性桥脑梗死患者，患者ABI不大于1.40。根据患者指数低（≤0.90）、边缘（0.91-1.10）、正常（1.11-1.40）分为三组。我们比较了两组患者早期神经功能恶化的指数，早期神经功能恶化的定义是在入院后的第一周内，在美国国立卫生研究院卒中量表（NIHSS）的运动项目上至少增加1分或在NIHSS总分上至少增加2分。结果：在我们分析的408例患者中，120例（29.4%）出现早期神经功能恶化。ABI分布：低，108例（26.5%）；边缘型，136例（33.3%）；正常人164例（40.2%）。在多元回归中，ABI的临界值（0.91-1.10）与早期神经功能恶化的风险显著降低相关（OR 0.457, 95% CI: 0.246-0.848），而低值（≤0.90）与早期神经功能恶化的风险显著升高相关（OR 1.975, 95% CI: 1.110-3.512）。结论：低ABI可以独立预测急性孤立性桥脑梗死后早期神经功能恶化的风险增加。相反，边缘ABI可以独立预测风险的降低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brain and Behavior BEHAVIORAL SCIENCES-NEUROSCIENCES

CiteScore

5.30

自引率

0.00%

发文量

352

审稿时长

14 weeks

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