Feeding development in healthy infants: A comparative framework for children with Spinal Muscular Atrophy – The DySMAnorm study

IF 1.2 4区医学 Q3 OTORHINOLARYNGOLOGY

International journal of pediatric otorhinolaryngology Pub Date : 2025-04-07 DOI:10.1016/j.ijporl.2025.112345

Charlotte Dumitrascu , Christina Pflug , Jun Oh , Mary Sengutta , Jonas Denecke , Jana Zang

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引用次数: 0

Abstract

Objectives

Normative data for swallowing parameters in non-dysphagic, healthy children for instrumental and clinical diagnostics are limited. In children with SMA, where due to the degenerative nature a deterioration in swallowing function in the first months of life is possible despite disease-modifying therapy, regular monitoring is required. The DySMA (Dysphagia in Spinal Muscular Atrophy) is a tool available to assess both physiological feeding development and specific abnormalities in children with SMA. We aimed to generate normative data for the DySMA in a sample of healthy infants to facilitate comparisons with children with SMA.

Methods

Healthy infants and toddlers aged zero to 24 months were recruited and divided into seven age groups. Two speech-language pathologists assessed the children according to the DySMA study protocol. The data were evaluated descriptively and the inter-rater reliability was calculated.

Results

A total of 92 healthy children were included. The DySMA total score ranged from 21 to 35 and showed excellent inter-rater reliability (ICC = .936; 95 % CI .752 to .984). The maximum score of 35 was first reached from 16 months onwards. Categories representing physiological development showed the most significant age-dependent changes, while no age-related development was observed in categories expressing pathology.

Conclusion

The DySMA effectively captures physiological feeding development. A higher total score reflects more comprehensive skills in children, while a lower score indicates a reduced range of abilities. By analyzing the normative sample, this tool makes it possible to represent a deviation from the norm for children with SMA.

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健康婴儿的喂养发育：脊髓性肌萎缩症儿童的比较框架-异常发育研究

目的对非吞咽困难、健康儿童的吞咽参数进行仪器和临床诊断的规范数据有限。对于患有SMA的儿童，尽管进行了疾病改善治疗，但由于退行性吞咽功能在出生后的头几个月仍可能恶化，因此需要定期监测。脊髓性肌萎缩症（脊髓性肌萎缩症中的吞咽困难）是一种可用于评估脊髓性肌萎缩症儿童生理喂养发育和特定异常的工具。我们的目的是在健康婴儿样本中生成DySMA的规范数据，以便与患有SMA的儿童进行比较。方法招募0 ~ 24月龄健康婴幼儿，分为7个年龄组。两名语言病理学家根据dyssma研究方案对儿童进行评估。对数据进行描述性评价，计算评分者间信度。结果共纳入92例健康儿童。DySMA总分在21 ~ 35分之间，表现出优异的量表间信度(ICC = .936；95%可信区间为。752至。984)。从16个月开始，第一次达到35分的最高分。代表生理发育的类别显示出最显著的年龄依赖性变化，而在表达病理的类别中没有观察到年龄相关的发展。结论DySMA能有效捕捉动物的生理摄食发育。总分越高，孩子的综合能力越强，分数越低，孩子的综合能力越弱。通过分析规范样本，该工具可以表示与SMA儿童规范的偏差。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International journal of pediatric otorhinolaryngology 医学-耳鼻喉科学

CiteScore

3.20

自引率

6.70%

发文量

276

审稿时长

62 days

期刊介绍： The purpose of the International Journal of Pediatric Otorhinolaryngology is to concentrate and disseminate information concerning prevention, cure and care of otorhinolaryngological disorders in infants and children due to developmental, degenerative, infectious, neoplastic, traumatic, social, psychiatric and economic causes. The Journal provides a medium for clinical and basic contributions in all of the areas of pediatric otorhinolaryngology. This includes medical and surgical otology, bronchoesophagology, laryngology, rhinology, diseases of the head and neck, and disorders of communication, including voice, speech and language disorders.