Echinatin inhibits the growth and metastasis of human hepatocellular carcinoma cells through p38 and JNK signaling pathways

IF 2.7 4区生物学 Q1 ANATOMY & MORPHOLOGY

Tissue & cell Pub Date : 2025-04-04 DOI:10.1016/j.tice.2025.102907

Jiayu Wang , Ziyun Li , Xueqian Han , Zhou Xie , Yajun Hou , Miao Liu , Yuhang Cheng , Qiuping Lu , Jinyong Luo , Hongbo Wang

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引用次数: 0

Abstract

Hepatocellular carcinoma (HCC) ranks among the most prevalent cancers, with both a high incidence and a significant mortality rate. Clinical medications are highly toxic to patients and prone to resistance. Natural products are highly valued in the development of antitumour drugs. This study aimed to elucidate the anti-HCC ability and potential mechanism of Echinatin (Ecn), a natural existed flavonoid. Our findings revealed that Ecn suppressed the growth, migration, and invasion of HCC cells and demonstrated a superior inhibitory impact on the development of xenograft tumors. Moreover, Ecn was less toxic to mice and had a good drug safety. Mechanistically, Ecn was found to activate p38 and JNK signaling pathways. Accordingly, the suppressive effect of Ecn on HCC cells was attenuated by the introduction of p38 blocker SB203580 and JNK blocker SP600125. Collectively, our research suggests that Ecn might have anti-HCC properties through the activation of p38 and JNK signaling.

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棘刺素通过p38和JNK信号通路抑制人肝癌细胞的生长和转移

肝细胞癌（HCC）是最常见的癌症之一，发病率高，死亡率高。临床用药对患者毒性大，容易产生耐药性。天然产物在抗肿瘤药物的开发中受到高度重视。本研究旨在阐明天然存在的黄酮类化合物刺青素（Echinatin, Ecn）的抗hcc能力及其潜在机制。我们的研究结果显示，Ecn抑制HCC细胞的生长、迁移和侵袭，并对异种移植肿瘤的发展表现出良好的抑制作用。Ecn对小鼠毒性较小，具有较好的用药安全性。机制上，Ecn被发现激活p38和JNK信号通路。因此，通过引入p38阻滞剂SB203580和JNK阻滞剂SP600125， Ecn对HCC细胞的抑制作用减弱。总之，我们的研究表明，Ecn可能通过激活p38和JNK信号传导而具有抗hcc的特性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tissue & cell 医学-解剖学与形态学

CiteScore

3.90

自引率

0.00%

发文量

234

期刊介绍： Tissue and Cell is devoted to original research on the organization of cells, subcellular and extracellular components at all levels, including the grouping and interrelations of cells in tissues and organs. The journal encourages submission of ultrastructural studies that provide novel insights into structure, function and physiology of cells and tissues, in health and disease. Bioengineering and stem cells studies focused on the description of morphological and/or histological data are also welcomed. Studies investigating the effect of compounds and/or substances on structure of cells and tissues are generally outside the scope of this journal. For consideration, studies should contain a clear rationale on the use of (a) given substance(s), have a compelling morphological and structural focus and present novel incremental findings from previous literature.