Different corpus callosum in panic disorder

IF 2.1 4区医学 Q3 CLINICAL NEUROLOGY

Psychiatry Research: Neuroimaging Pub Date : 2025-04-05 DOI:10.1016/j.pscychresns.2025.111990

Halim Ömer Kaşikci , Sema Baykara , Hale Nur Balci , Murat Baykara

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引用次数: 0

Abstract

Background

Despite hypotheses regarding the neurobiology of panic disorder (PD), its neurobiological basis is still unknown. Study results support that the individual differences in corpus callosum (CC) properties could reflect trait based alterations that predispose individuals to higher anxiety sensitivity, and to disorders associated with stress such as PD. Neuroimaging studies with panic disorder have not been sufficient to explain the pathophysiology of the disease. The aim of this study is to provide additional information for studies examining the etiology of PD by comparing the corpus callosum, a region associated with attention, anxiety, and somatic complaints, on sagittal MRI images of PD patients with the corpus callosum of healthy individuals.

Methods

T2-weighted MRI images of 164 patients diagnosed with PD and 78 controls selected from Hospital Information System (HIS) and meeting the study criteria were evaluated by shape analysis method.

Results

There were differences between the shapes and areas of the CC in the mid-sagittal images of the PD patients and healthy controls.

Conclusions

This study findings highlighted the variable dimensional and subregional properties of CC in PD patients. This study could shed light on future studies about PD etiology, diagnosis and treatment.

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惊恐障碍的不同胼胝体

背景：尽管对惊恐障碍（PD）的神经生物学有一些假设，但其神经生物学基础仍不清楚。研究结果支持胼胝体（CC）特性的个体差异可能反映了基于性状的改变，这些改变使个体易患更高的焦虑敏感性，以及与PD等压力相关的疾病。惊恐障碍的神经影像学研究还不足以解释该疾病的病理生理学。本研究的目的是通过比较PD患者和健康人胼胝体矢状面MRI图像上的胼胝体（与注意力、焦虑和躯体不适相关的区域），为检查PD病因的研究提供额外的信息。方法从医院信息系统（HIS）中选取符合研究标准的164例PD患者和78例对照患者的st2加权MRI图像，采用形状分析法进行评价。结果PD患者中矢状面图像中CC的形状和面积与正常对照存在差异。结论本研究结果突出了PD患者CC的可变尺寸和分区域特征。本研究对今后PD病因、诊断和治疗的研究具有一定的指导意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Psychiatry Research: Neuroimaging 医学-精神病学

CiteScore

3.80

自引率

0.00%

发文量

审稿时长

22.5 weeks

期刊介绍： The Neuroimaging section of Psychiatry Research publishes manuscripts on positron emission tomography, magnetic resonance imaging, computerized electroencephalographic topography, regional cerebral blood flow, computed tomography, magnetoencephalography, autoradiography, post-mortem regional analyses, and other imaging techniques. Reports concerning results in psychiatric disorders, dementias, and the effects of behaviorial tasks and pharmacological treatments are featured. We also invite manuscripts on the methods of obtaining images and computer processing of the images themselves. Selected case reports are also published.