Exploring software tools for comparative evaluation of radiation attenuation parameters in various drugs across gamma, electron, neutron, and ion radiations

IF 2.8 3区物理与天体物理 Q3 CHEMISTRY, PHYSICAL

Radiation Physics and Chemistry Pub Date : 2025-04-07 DOI:10.1016/j.radphyschem.2025.112794

N.A. Kotb , O.A. El-Kawy , A.M. Abdelmonem

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引用次数: 0

Abstract

This study investigates the radiation attenuation parameters for some commonly used pharmaceutical drugs like diazepam, ibutilide, levofloxacin, ibuprofen, ranitidine, and celecoxib, which are crucial for medical applications. Through computational analyses employing advanced software tools such as Phy-X/PSD, Py-MLBUF, GRASP, SRIM Monte Carlo, and ESTAR NIST, the mass attenuation coefficient, linear attenuation coefficient, half-value layer, mean free path, effective atomic number, and effective electron density were determined across a broad energy spectrum. Additionally, ionizing radiation interactions with gamma rays, ion particles (H⁺, He²⁺, Bi³⁺, Ti⁴⁺, Gd³⁺, and In³⁺), and electrons were examined, along with fast neutron removal cross-section (FNRCS) and macroscopic effective removal cross-section (MRCS). The results offer valuable insights applicable to radiation physics, pharmacology, and medical physics, enhancing understanding of radiation-drug interactions essential for medical diagnostics and therapies.

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探索各种药物在伽马、电子、中子和离子辐射下的辐射衰减参数比较评估的软件工具

本研究研究了一些常用药物的辐射衰减参数，如地西泮、伊布利特、左氧氟沙星、布洛芬、雷尼替丁、塞来昔布等，这些药物在医疗应用中至关重要。利用Phy-X/PSD、Py-MLBUF、GRASP、SRIM Monte Carlo和ESTAR NIST等先进的软件工具进行计算分析，确定了宽能谱范围内的质量衰减系数、线性衰减系数、半值层、平均自由程、有效原子序数和有效电子密度。此外，研究了电离辐射与伽马射线、离子粒子（H+、He2+、Bi3+、Ti4+、Gd3+和In3+）和电子的相互作用，以及快中子去除截面（FNRCS）和宏观有效去除截面（MRCS）。研究结果为放射物理学、药理学和医学物理学提供了有价值的见解，增强了对医学诊断和治疗所必需的辐射-药物相互作用的理解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Radiation Physics and Chemistry 化学-核科学技术

CiteScore

5.60

自引率

17.20%

发文量

574

审稿时长

12 weeks

期刊介绍： Radiation Physics and Chemistry is a multidisciplinary journal that provides a medium for publication of substantial and original papers, reviews, and short communications which focus on research and developments involving ionizing radiation in radiation physics, radiation chemistry and radiation processing. The journal aims to publish papers with significance to an international audience, containing substantial novelty and scientific impact. The Editors reserve the rights to reject, with or without external review, papers that do not meet these criteria. This could include papers that are very similar to previous publications, only with changed target substrates, employed materials, analyzed sites and experimental methods, report results without presenting new insights and/or hypothesis testing, or do not focus on the radiation effects.