Factors influencing the development of osteoporosis in elderly patients with rheumatoid arthritis.

Yanru Yang, Ying Chen, Li Zhang, Xiaofeng Yang, Jingquan Qiao
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Abstract

Background: To explore the influencing factors of osteoporosis (OP) in elderly patients with rheumatoid arthritis (RA).

Methodology: A total of 145 elderly patients with RA were divided into comorbidity group (with OP) of 79 patients and RA group (without OP) of 66 patients. Demographic data and laboratory parameters were collected from patients. Demographic characteristics and laboratory parameters were compared between the two groups. Multiple influencing factors of OP in RA patients were analysed.

Results: There were significant differences in age, BMI, primary disease duration, history of glucocorticoids (GC) administration, disease activity score in 28 joints (DAS-28), and Sharp score data between the two groups. There were significant differences in rheumatoid factor (RF), interleukin-27 (IL-27), procollagen I N-Terminal Propeptide (PINP), nuclear receptor of activator factor-κB ligand (RANKL), and 25-hydroxyvitamin D [25-hydroxyvitamin D, 25 (OH) D] data between the two groups (P < 0.05). Logistic analysis showed that age, primary disease duration, GC history, DAS-28, Sharp score, RANKL and 25 (OH) D were independent factors for OP in RA patients.

Conclusion: The risk of OP in elderly RA patients is mainly related to age, primary disease duration, GC history, DAS-28, Sharp score, RANKL, and 25 (OH) D levels, and risk factors should be actively prevented.

影响老年类风湿关节炎患者骨质疏松发生的因素。
背景:探讨老年类风湿关节炎(RA)患者骨质疏松症(OP)的影响因素。方法:145例老年RA患者分为合并症组(合并OP) 79例和RA组(不合并OP) 66例。收集患者的人口学数据和实验室参数。比较两组患者的人口学特征和实验室参数。分析了影响RA患者OP的多种因素。结果:两组患者的年龄、BMI、原发病程、糖皮质激素(GC)使用史、28个关节疾病活动度评分(DAS-28)、Sharp评分数据均有显著差异。两组患者类风湿因子(RF)、白细胞介素-27 (IL-27)、前胶原I n端前肽(PINP)、活化因子κ b核受体配体(RANKL)、25-羟基维生素D[25-羟基维生素D, 25 (OH) D]数据差异均有统计学意义(P < 0.05)。Logistic分析显示,年龄、原发病程、GC史、DAS-28、Sharp评分、RANKL、25 (OH) D是影响RA患者OP的独立因素。结论:老年RA患者OP发生风险主要与年龄、原发病程、GC史、DAS-28、Sharp评分、RANKL、25 (OH) D水平有关,应积极预防危险因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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