The Luganda Edinburgh Postnatal depression scale: cross-cultural adaptation and validation for prenatal screening of depression in a Ugandan sample.

David Christopher Mukasa, Sam Ononge, Imelda Namagembe, Josaphat Byamugisha, Musa Sekikubo, Mark Muyingo, Noeline Nakasujja
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Abstract

Background: Depression affects approximately 364 million people globally. Prenatal depression affects between 26.3% and 32.9% of mothers in Africa. Opportunities for prenatal screening are missed. The gold standard diagnostic, the Diagnostic and Statistical Manual of Mental Disorders-Fifth edition (DSM-5) criteria for Major Depressive Disorder (MDD) has higher technical requirement. There is inadequate information on locally adapted and validated user-friendly screening tools in Uganda.

Objective: To Adapt and validate the Luganda Edinburgh Postnatal Depression Scale (EPDS-L) for screening prenatal depression at Kawempe National Referral hospital (KNRH).

Methods: Cross-sectional study in KNRH using International Society for Pharmacoeconomics and Outcomes Research guidelines for adaptation and quantitative approaches for the validation. Consecutive sampling until the desired sample of 100, all participants responded to both EPDS-L and DSM-5 criteria for MDD. Reliability demonstrated using Cronbach's alpha coefficient, while validity was demonstrated by sensitivity, specificity, Negative Predictive Value (NPV), Positive Predictive Value (PPV) and Area-Under-the-curve (AUC).

Results: EPDS-L had Cronbach's-Alpha of 0.8515. At cut-off of 13, sensitivity was 62.86%, specificity-100%, PPV-100% and NPV-83.3%. AUC was 0.99. Performance was better at cut-off of 10, with sensitivity-97.14% and specificity-98.46%.

Conclusion: The EPDS-L is reliable at cut-off of 13 but performs even better at cut-off of 10.

卢甘达爱丁堡产后抑郁量表:乌干达样本中抑郁症产前筛查的跨文化适应和验证。
背景:全球约有3.64亿人患有抑郁症。在非洲,26.3%至32.9%的母亲患有产前抑郁症。错过了产前筛查的机会。诊断金标准《精神障碍诊断与统计手册-第五版》(DSM-5)对重度抑郁症(MDD)的诊断标准有较高的技术要求。乌干达关于经当地调整和验证的用户友好筛查工具的信息不足。目的:适应并验证卢甘达爱丁堡产后抑郁量表(EPDS-L)在卡温佩国家转诊医院(KNRH)产前抑郁筛查中的应用。方法:采用国际药物经济学和结果研究学会的适应性指南和定量方法对KNRH进行横断面研究。连续抽样,直到所需的100个样本,所有参与者都对EPDS-L和DSM-5的MDD标准有反应。信度采用Cronbach’s alpha系数,效度采用敏感性、特异性、负预测值(NPV)、正预测值(PPV)和曲线下面积(AUC)。结果:EPDS-L的Cronbach's-Alpha值为0.8515。截止值为13时,敏感性为62.86%,特异性为100%,PPV-100%, NPV-83.3%。AUC为0.99。截止值为10时,灵敏度为97.14%,特异性为98.46%。结论:EPDS-L在截止值为13时是可靠的,但在截止值为10时表现更好。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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