Alleviation of nephropathy during aging as complications of diabetic by natural products.

Abstract

Background: The most complications of chronic diseases as diabetic during aging is micro and microvascular disorders. Consumption of functional foods is very important in protection from these complications. We studied the impact of dipeptide anserine in combination with vitamin E in prevention diabetic nephropathy in diabetic rats.

Methods: The study included 60 male albino rats sorted into five groups: GP (I): control and the other rat groups were induced diabetic by a single dose of streptozocine i.p, at dose of (55 mg/kg/b.w).GP II was considered as diabetic untreated. The other diabetic groups were treated with anserine (1mg/kg b.w, i.p), α-tocopherol (50, 00 IU/kg b.w) or combined. After 12 weeks, fasting serum was subjected for assay of glucose, glycated hemoglobin (HA1c), advanced glycated end products (AGEs), oxidative stress markers (MDA, SOD) and inflammatory markers (TNF-α and IL-6).

Results: Data obtained revealed that, diabetic rats treated with anserine or α-tocopherol or combination improve abnormalities, glucose, HA1c, antioxidant enzymes, inflammatory mediators and AGEs versus untreated diabetic.

Conclusion: Dietary supplement of natural products as anserine and α-tocopherol protect against micro and microvascular system, which is suggestive as alternative or complementary therapeutic agents for diabetic complications as neuropathy, nephropathy, and CVD.