Prevalence and antimicrobial susceptibility pattern of coagulase-negative Staphylococci isolated from ocular infections: A systematic review and meta-analysis

IF 5.9 1区医学 Q1 OPHTHALMOLOGY

Ocular Surface Pub Date : 2025-04-04 DOI:10.1016/j.jtos.2025.03.006

Abolfazl Rafati Zomorodi , Maryam Mohammadi , Zahra Gholizadeh Farshi , Mohammad Hassan Parvizi Mashhadi , Sasan Pourbagher Benam , Mohammad Motamedifar

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引用次数: 0

Abstract

Bacteria are the leading cause of ocular infections (OIs), accounting for 32 %–74 % of cases globally. Coagulase-negative Staphylococci (CoNS) are frequently identified as the main causative pathogens of all types of OIs. This study systematically reviewed the prevalence of CoNS and their resistance rates to ciprofloxacin, chloramphenicol, tetracycline, and trimethoprim/sulfamethoxazole in OIs worldwide.

We conducted a comprehensive search of publications from January 1, 2000, to May 19, 2024, using three major databases: Scopus, Web of Science, and PubMed. Statistical analyses were performed with Stata 14.0, employing the Metaprop package to calculate pooled prevalence and confidence intervals. A random-effects model with double arcsine transformations stabilized variance in meta-analyses, and publication bias was evaluated using the “metabias” command. If bias was detected, we adjusted prevalence using the trim-and-fill method. A significant level of 0.05 was set for all analyses.

Out of 2116 articles, 214 were eligible for data extraction. The pooled prevalence of CoNS isolates in OIs was 25 % (95 % CI: 21–28; I² = 99.7 %), with Europe showing the highest prevalence at 30 % (95 % CI: 15–46; I²: 99.9 %) and Asia the lowest at 21 % (95 % CI: 19–24; I²: 98.68 %). The pooled prevalence of resistance among CoNS isolates from patients with OIs was 27 % (95 % CI: 19–35) for ciprofloxacin, 23 % (95 % CI: 12–34) for chloramphenicol, 41 % (95 % CI: 33–49) for tetracycline, and 40 % (95 % CI: 29–51) for trimethoprim/sulfamethoxazole.

In conclusion, CoNS are significant pathogens in OIs, highlighting the need for improved diagnostic tests and updated management guidelines globally.

查看原文本刊更多论文

眼部感染中分离的凝固酶阴性葡萄球菌的患病率和抗菌药物敏感性模式：一项系统综述和荟萃分析。

细菌是眼部感染的主要原因，占全球病例的32%至74%。凝固酶阴性葡萄球菌（con）常被认为是所有类型oi的主要致病病原体。本研究系统回顾了全球oi中con的患病率及其对环丙沙星、氯霉素、四环素和甲氧苄啶/磺胺甲恶唑的耐药率。我们对2000年1月1日至2024年5月19日的出版物进行了全面的检索，使用了三个主要数据库：Scopus， Web of Science和PubMed。采用Stata 14.0进行统计分析，采用Metaprop软件包计算总患病率和置信区间。采用双反正弦变换的随机效应模型稳定了meta分析中的方差，并使用“meta”命令评估发表偏倚。如果检测到偏倚，我们使用修整填充法调整患病率。所有分析的显著水平为0.05。在2,116篇文章中，214篇符合数据提取条件。在oi中，con分离株的总患病率为25% (95% CI: 21-28；I2 = 99.7%)，欧洲的患病率最高，为30% (95% CI: 15-46；I2: 99.9%)，亚洲最低，为21% (95% CI: 19-24；I2: 98.68%)。来自OIs患者的con分离株的总耐药率为环丙沙星27% (95% CI: 19-35)，氯霉素23% (95% CI: 12-34)，四环素41% (95% CI: 33-49)，甲氧苄啶/磺胺甲恶唑40% （95% CI: 29-51）。总之，con是oi的重要病原体，这突出了全球改进诊断检测和更新管理指南的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ocular Surface 医学-眼科学

CiteScore

11.60

自引率

14.10%

发文量

审稿时长

39 days

期刊介绍： The Ocular Surface, a quarterly, a peer-reviewed journal, is an authoritative resource that integrates and interprets major findings in diverse fields related to the ocular surface, including ophthalmology, optometry, genetics, molecular biology, pharmacology, immunology, infectious disease, and epidemiology. Its critical review articles cover the most current knowledge on medical and surgical management of ocular surface pathology, new understandings of ocular surface physiology, the meaning of recent discoveries on how the ocular surface responds to injury and disease, and updates on drug and device development. The journal also publishes select original research reports and articles describing cutting-edge techniques and technology in the field. Benefits to authors We also provide many author benefits, such as free PDFs, a liberal copyright policy, special discounts on Elsevier publications and much more. Please click here for more information on our author services. Please see our Guide for Authors for information on article submission. If you require any further information or help, please visit our Support Center