Survival Outcomes of the Patients With Advanced Hypopharyngeal Squamous Cell Carcinoma Treated With Chemoradiotherapy and Total Pharyngolaryngectomy Based on Reports of Head and Neck Cancer Registry of Japan.

IF 2.3 3区医学 Q1 OTORHINOLARYNGOLOGY

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2025-04-07 DOI:10.1002/hed.28162

Yuto Horichi, Hirotaka Shinomiya, Megumi Kitayama, Daisuke Kawakita, Takeshi Kodaira, Munenaga Nakamizo, Seiichi Yoshimoto, Ken-Ichi Nibu

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引用次数: 0

Abstract

Background: For laryngeal preservation in locally advanced hypopharyngeal cancer (HPC), the role of induction chemotherapy (ICT) and chemoradiotherapy (CRT) as alternatives to total pharyngolaryngectomy (TPL) remains unclear.

Methods: We analyzed 825 patients with T3N0-2M0 and 900 with T4aN0-2M0 HPC from the Head and Neck Cancer Registry of Japan (2011-2015). Oncological outcomes of ICT, CRT, and TPL were evaluated. Propensity score matching analysis (PSM) was performed between TPL and CRT, excluding ICT.

Results: In T4aN0-2M0 patients, ICT followed by TPL significantly improved overall survival and local recurrence-free survival (LRFS) compared with TPL, and ICT followed by CRT significantly improved LRFS compared with CRT. No significant differences in survival were observed between TPL and CRT in both T3N0-2M0 and T4aN0-2M0 patients in PSM.

Conclusions: ICT benefited T4aN0-2M0 patients. CRT did not compromise survival compared with TPL in T3-4aN0-2M0 patients, supporting the rationale of ICT and CRT for advanced HPC.

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晚期下咽鳞状细胞癌放化疗和全咽喉癌切除术患者的生存结局——基于日本头颈癌登记报告

背景：对于局部晚期下咽癌（HPC）的喉保存，诱导化疗（ICT）和放化疗（CRT）作为全咽切除术（TPL）的替代方案的作用尚不清楚。方法：我们分析了来自日本头颈癌登记处（2011-2015）的825例T3N0-2M0和900例T4aN0-2M0 HPC患者。评估ICT、CRT和TPL的肿瘤预后。在TPL和CRT之间进行倾向评分匹配分析（PSM），不包括ICT。结果：t4an0 ~ 2m0患者，ICT + TPL较TPL显著提高总生存率和局部无复发生存率（LRFS）， ICT + CRT较CRT显著提高LRFS。T3N0-2M0和T4aN0-2M0 PSM患者TPL与CRT生存率无显著差异。结论：ICT使T4aN0-2M0患者受益。与TPL相比，T3-4aN0-2M0患者的CRT没有影响生存，支持ICT和CRT治疗晚期HPC的基本原理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 医学-耳鼻喉科学

CiteScore

7.00

自引率

6.90%

发文量

278

审稿时长

1.6 months

期刊介绍： Head & Neck is an international multidisciplinary publication of original contributions concerning the diagnosis and management of diseases of the head and neck. This area involves the overlapping interests and expertise of several surgical and medical specialties, including general surgery, neurosurgery, otolaryngology, plastic surgery, oral surgery, dermatology, ophthalmology, pathology, radiotherapy, medical oncology, and the corresponding basic sciences.