Psychological and immunological associations with movement-evoked low back pain among older adults.

IF 3.1 Q2 NEUROSCIENCES
Pain Reports Pub Date : 2025-04-03 eCollection Date: 2025-06-01 DOI:10.1097/PR9.0000000000001262
Riley Kahan, Arthur Woznowski-Vu, Janet L Huebner, Carl F Pieper, Adam P Goode, Steven Z George, Timothy H Wideman, Virginia Byers Kraus, Cathleen Colón-Emeric, Corey B Simon
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Abstract

Introduction: Low back pain (LBP) is a leading global factor in disability among older adults. Movement-evoked pain (MEP) is potentially an important mediator in the disability pathway but is predominantly tested in the laboratory.

Objectives: We aimed to explore MEP in the natural environment ("daily" MEP) and its correlation with laboratory MEP, along with potential psychological and immunological influences.

Method: Thirty-five older adults with persistent LBP attended a single laboratory session. Pain catastrophizing, pain-related fear of movement, and pain self-efficacy were measured by questionnaire. Resting inflammation and inflammatory reactivity to painful movement were evaluated using serum interleukin-6, tissue necrosis factor alpha, and C-reactive protein (CRP). Laboratory MEP was defined by aggregate pain intensity with a movement provocation test. Daily MEP was measured for the next 7 days using ecological momentary assessment.

Results: Laboratory MEP was strongly correlated with daily MEP (ρ = 0.780, P = <0.001). C-reactive protein (Hedges [g] = 0.266) and interleukin-6 (g = 0.433) demonstrated small to moderate reactivity to painful movement. After controlling for age and multimorbidity, pain catastrophizing and pain self-efficacy explained 24% to 37% variance in laboratory and daily MEP. Resting inflammatory markers were not associated with MEP; however, C-reactive protein reactivity to painful movement explained 19% to 25% variance in laboratory and daily MEP.

Conclusion: Preliminary indication is that laboratory and daily MEP may be proxy measures for one another, and that MEP is influenced by psychological and immunological factors. Future studies will aim to (1) validate findings among older adults with persistent LBP and (2) for clinical phenotyping, clarify complex relationships among psychological and immunological factors with disability pathway components like MEP.

Abstract Image

Abstract Image

老年人运动诱发腰痛的心理和免疫关联。
简介:腰痛(LBP)是老年人残疾的主要全球因素。运动诱发疼痛(MEP)在残疾通路中可能是一个重要的中介,但主要在实验室进行测试。目的:我们旨在探讨自然环境中的MEP(“日常”MEP)及其与实验室MEP的相关性,以及潜在的心理和免疫影响。方法:35名患有持续性腰痛的老年人参加了一次实验室会议。采用问卷调查的方法测量疼痛灾难化、疼痛相关的运动恐惧和疼痛自我效能。通过血清白细胞介素-6、组织坏死因子α和c反应蛋白(CRP)评估静息炎症和对疼痛运动的炎症反应性。实验室MEP是通过运动激发试验的总疼痛强度来定义的。采用瞬时生态评价法测定7 d的每日生态环境能。结果:实验室MEP与日常MEP呈正相关(ρ = 0.780, P = g] = 0.266),白细胞介素-6 (g = 0.433)对疼痛运动表现出小至中度反应。在控制了年龄和多发病因素后,疼痛灾难化和疼痛自我效能解释了实验室和日常MEP的24%至37%的差异。静息炎症标志物与MEP无关;然而,c反应蛋白对疼痛运动的反应性解释了实验室和日常MEP中19%至25%的差异。结论:初步提示实验室和日常MEP可能是相互替代的,MEP受心理和免疫因素的影响。未来的研究将旨在(1)验证老年持续性腰痛患者的研究结果,(2)临床表型,阐明心理和免疫因素与MEP等残疾途径组分之间的复杂关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Pain Reports
Pain Reports Medicine-Anesthesiology and Pain Medicine
CiteScore
7.50
自引率
2.10%
发文量
93
审稿时长
8 weeks
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