Cell-based regenerative and rejuvenation strategies for treating neurodegenerative diseases.

IF 7.1 2区医学 Q1 CELL & TISSUE ENGINEERING

Stem Cell Research & Therapy Pub Date : 2025-04-06 DOI:10.1186/s13287-025-04285-7

Sixiu Deng, Huangfan Xie, Bingqing Xie

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Abstract

Neurodegenerative diseases including Alzheimer's and Parkinson's disease are age-related disorders which severely impact quality of life and impose significant societal burdens. Cellular senescence is a critical factor in these disorders, contributing to their onset and progression by promoting permanent cell cycle arrest and reducing cellular function, affecting various types of cells in brain. Recent advancements in regenerative medicine have highlighted "R3" strategies-rejuvenation, regeneration, and replacement-as promising therapeutic approaches for neurodegeneration. This review aims to critically analyze the role of cellular senescence in neurodegenerative diseases and organizes therapeutic approaches within the R3 regenerative medicine paradigm. Specifically, we examine stem cell therapy, direct lineage reprogramming, and partial reprogramming in the context of R3, emphasizing how these interventions mitigate cellular senescence and counteracting aging-related neurodegeneration. Ultimately, this review seeks to provide insights into the complex interplay between cellular senescence and neurodegeneration while highlighting the promise of cell-based regenerative strategies to address these debilitating conditions.

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基于细胞的再生和年轻化策略治疗神经退行性疾病。

包括阿尔茨海默病和帕金森病在内的神经退行性疾病是与年龄有关的疾病，严重影响生活质量并造成重大的社会负担。细胞衰老是这些疾病的关键因素，通过促进永久性细胞周期停滞和降低细胞功能，影响大脑中各种类型的细胞，从而促进其发生和发展。再生医学的最新进展突出了“R3”策略——恢复活力、再生和替代——作为神经退行性疾病的有前途的治疗方法。这篇综述旨在批判性地分析细胞衰老在神经退行性疾病中的作用，并在R3再生医学范式中组织治疗方法。具体来说，我们在R3的背景下研究了干细胞治疗、直接谱系重编程和部分重编程，强调这些干预措施如何减轻细胞衰老和对抗与衰老相关的神经变性。最后，本综述旨在深入了解细胞衰老和神经退行性变之间的复杂相互作用，同时强调基于细胞的再生策略解决这些衰弱性疾病的前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Stem Cell Research & Therapy CELL BIOLOGY-MEDICINE, RESEARCH & EXPERIMENTAL

CiteScore

13.20

自引率

8.00%

发文量

525

审稿时长

1 months

期刊介绍： Stem Cell Research & Therapy serves as a leading platform for translational research in stem cell therapies. This international, peer-reviewed journal publishes high-quality open-access research articles, with a focus on basic, translational, and clinical research in stem cell therapeutics and regenerative therapies. Coverage includes animal models and clinical trials. Additionally, the journal offers reviews, viewpoints, commentaries, and reports.