Erlotinib-Conjugated O-Phenylenediamine Derived Fluorescent Carbon Nanodots (OPD@CD) Platform for Targeting Breast Cancer (MCF-7) Cells.

IF 2.6 4区化学 Q2 BIOCHEMICAL RESEARCH METHODS

Journal of Fluorescence Pub Date : 2025-04-07 DOI:10.1007/s10895-025-04279-x

Ali Ibrahim Shkhair, Anju S Madanan, Susan Varghese, Merin K Abraham, Geneva Indongo, Greeshma Rajeevan, Arathy B K, Sara Muneer Abbas, Sony George

引用次数: 0

Abstract

Breast cancer continues to be a complicated and pervasive health issue that impacts women worldwide. Fluorescent nanoparticles, in particular, provide significant potential for imaging and drug delivery in cancer cells. We describe the utilization of o-phenylenediamine carbon nanodots (OPD@CD) as fluorescent agents for in vitro imaging and drug delivery of breast cancer cells. The surface of OPD@CD was modified with the tyrosine kinase inhibition anticancer drug - erlotinib. The drug specifically targets human breast cancer cell lines (MCF-7) that overexpress the epidermal growth factor receptor (EGFR). The confocal luminescence microscopic photographs exhibit sufficient luminescence staining in MCF-7 cells.

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厄洛替尼偶联邻苯二胺衍生的荧光碳纳米点（OPD@CD）靶向乳腺癌（MCF-7）细胞平台。

乳腺癌仍然是一个影响全世界妇女的复杂和普遍的健康问题。特别是荧光纳米颗粒，为癌细胞成像和药物输送提供了巨大的潜力。我们描述了利用邻苯二胺碳纳米点（OPD@CD）作为荧光剂的体外成像和乳腺癌细胞的药物输送。用酪氨酸激酶抑制抗癌药物厄洛替尼对OPD@CD表面进行修饰。该药物专门针对过度表达表皮生长因子受体（EGFR）的人乳腺癌细胞系（MCF-7）。共聚焦显微照片显示MCF-7细胞有足够的发光染色。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Fluorescence 化学-分析化学

CiteScore

4.60

自引率

7.40%

发文量

203

审稿时长

5.4 months

期刊介绍： Journal of Fluorescence is an international forum for the publication of peer-reviewed original articles that advance the practice of this established spectroscopic technique. Topics covered include advances in theory/and or data analysis, studies of the photophysics of aromatic molecules, solvent, and environmental effects, development of stationary or time-resolved measurements, advances in fluorescence microscopy, imaging, photobleaching/recovery measurements, and/or phosphorescence for studies of cell biology, chemical biology and the advanced uses of fluorescence in flow cytometry/analysis, immunology, high throughput screening/drug discovery, DNA sequencing/arrays, genomics and proteomics. Typical applications might include studies of macromolecular dynamics and conformation, intracellular chemistry, and gene expression. The journal also publishes papers that describe the synthesis and characterization of new fluorophores, particularly those displaying unique sensitivities and/or optical properties. In addition to original articles, the Journal also publishes reviews, rapid communications, short communications, letters to the editor, topical news articles, and technical and design notes.