Increased risk of suicide among individuals with chronic obstructive pulmonary disease: A nationwide cohort study in Korea

IF 4.9 2区医学 Q1 CLINICAL NEUROLOGY

Journal of affective disorders Pub Date : 2025-04-04 DOI:10.1016/j.jad.2025.04.022

Sang Hyuk Kim , Ji-Yong Moon , Taehee Kim , Jin-Hyung Jung , Kyungdo Han , Kyung Hoon Min , Hyun Lee

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引用次数: 0

Abstract

Background

Previous studies have established that individuals with chronic obstructive pulmonary disease (COPD) have an increased risk of suicidal behaviors. However, it is uncertain which subgroups of individuals with COPD are at higher risk of suicide.

Method

We analyzed data from the Korean National Health Insurance Service. The exposure was COPD, and the outcome was death by suicide. Participants were followed until their date of death by suicide, the censoring date, or December 31, 2021, whichever came first. A Fine-Gray proportional hazards model for subdistribution was used to determine the associations between COPD and death by suicide.

Results

During a median follow-up of 11.3 years (interquartile range, 11.1–11.6 years), individuals with COPD had an increased risk of death by suicide compared to those without (adjusted subdistribution hazard ratio [aSHR] = 1.20, 95 % confidence interval [CI] = 1.08–1.32). When stratified by the presence or absence of potential risk factors and COPD, the risk of suicide was highest in the COPD population with current smoking habits ≥20 PY (aSHR = 1.71, 95 % CI = 1.39–2.12), depression (aSHR = 2.46, 95 % CI = 1.97–3.08), and anxiety (aSHR = 2.71, 95 % CI = 1.87–3.92) compared to their corresponding reference groups (non-COPD population without the corresponding potential risk factors).

Conclusions

COPD increased the risk of death by suicide. This risk was particularly pronounced when current heavy smoking habits, depression, and anxiety coexisted with COPD.

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慢性阻塞性肺疾病患者自杀风险增加：韩国一项全国性队列研究

背景：以往的研究已经证实，慢性阻塞性肺疾病（COPD）患者有更高的自杀行为风险。然而，尚不确定哪些COPD患者亚组自杀风险更高。方法：我们分析了韩国国民健康保险公团的数据。这种暴露是慢性阻塞性肺病，结果是自杀死亡。参与者被跟踪到他们自杀的日期，审查日期，或2021年12月31日，以先到者为准。亚分布的细灰色比例风险模型用于确定COPD与自杀死亡之间的关系。结果：在中位随访11.3 年（四分位数范围11.1-11.6 年）期间，COPD患者的自杀死亡风险高于无COPD患者（调整后亚分布风险比[aSHR] = 1.20,95 %置信区间[CI] = 1.08-1.32）。分类时,潜在的风险因素的存在与否和慢性阻塞性肺病,自杀的风险是最高的慢性阻塞性肺病人口与当前吸烟习惯≥20 PY (aSHR = 1.71,95 CI  % = 1.39 - -2.12)、抑郁(aSHR = 2.46,95 CI  % = 1.97 - -3.08),和焦虑(aSHR = 2.71,95 CI  % = 1.87 - -3.92)相比,相应的参照群体(non-COPD人口没有相应的潜在风险因素)。结论：COPD增加了自杀死亡的风险。当当前重度吸烟习惯、抑郁和焦虑与COPD共存时，这种风险尤为明显。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of affective disorders 医学-精神病学

CiteScore

10.90

自引率

6.10%

发文量

1319

审稿时长

9.3 weeks

期刊介绍： The Journal of Affective Disorders publishes papers concerned with affective disorders in the widest sense: depression, mania, mood spectrum, emotions and personality, anxiety and stress. It is interdisciplinary and aims to bring together different approaches for a diverse readership. Top quality papers will be accepted dealing with any aspect of affective disorders, including neuroimaging, cognitive neurosciences, genetics, molecular biology, experimental and clinical neurosciences, pharmacology, neuroimmunoendocrinology, intervention and treatment trials.