Effect of premature luteinizing hormone surge on pregnancy outcomes in intracytoplasmic sperm injection or in vitro fertilization cycles.

IF 3.1 3区医学 Q1 MEDICINE, GENERAL & INTERNAL

Frontiers in Medicine Pub Date : 2025-03-21 eCollection Date: 2024-01-01 DOI:10.3389/fmed.2024.1429033

Maram Aldarsooni, Mohammad Alfarah, Fatimah Albohammod, Dania Al-Jaroudi

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Abstract

Background: A premature surge in luteinizing hormone (LH) during ovarian stimulation cycles between 12 and 25% has been commonly reported. However, there is still a lack of consensus on whether premature LH surge affects pregnancy outcomes.

Objective: This study aimed to evaluate the effect of premature LH surge on pregnancy rates in women with and without premature LH surge during intracytoplasmic sperm injection or stimulation of in vitro fertilization cycles at a tertiary hospital in Riyadh, Saudi Arabia.

Materials and methods: A cross-sectional study was conducted. Information related to 771 women who had IVF/ICSI cycles between January 2022 and December 2022 was reviewed. Patients were divided into two groups based on premature LH surge.

Results: There was no significant difference in patients' characteristics. The live birth rates were significantly higher in women without premature LH surge than in women with LH surge (12.9% vs. 5.6%) (p = 0.010). With regard to the number of oocytes collected, M2, and fertilization rate, these were significantly higher in women without premature LH surge, with p-values of 0.001, 0.002, and 0.004, respectively.

Conclusion: The study demonstrates significantly higher live birth rates in women without premature LH surge.

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来源期刊

Frontiers in Medicine Medicine-General Medicine

CiteScore

5.10

自引率

5.10%

发文量

3710

审稿时长

12 weeks

期刊介绍： Frontiers in Medicine publishes rigorously peer-reviewed research linking basic research to clinical practice and patient care, as well as translating scientific advances into new therapies and diagnostic tools. Led by an outstanding Editorial Board of international experts, this multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. In addition to papers that provide a link between basic research and clinical practice, a particular emphasis is given to studies that are directly relevant to patient care. In this spirit, the journal publishes the latest research results and medical knowledge that facilitate the translation of scientific advances into new therapies or diagnostic tools. The full listing of the Specialty Sections represented by Frontiers in Medicine is as listed below. As well as the established medical disciplines, Frontiers in Medicine is launching new sections that together will facilitate - the use of patient-reported outcomes under real world conditions - the exploitation of big data and the use of novel information and communication tools in the assessment of new medicines - the scientific bases for guidelines and decisions from regulatory authorities - access to medicinal products and medical devices worldwide - addressing the grand health challenges around the world