Successful Treatment of Fournier's Gangrene in Child with Relapsed Acute Lymphoblastic Leukemia: Case Report and Review of the Literature.

IF 2.9 3区医学 Q2 INFECTIOUS DISEASES

Infection and Drug Resistance Pub Date : 2025-04-01 eCollection Date: 2025-01-01 DOI:10.2147/IDR.S490240

Julia Kołodziejczyk, Jakub Czarny, Stanisław Królak, Sandra Rutkowska, Sebastian Moryciński, Przemysław Mańkowski, Alicja Bartkowska-Śniatkowska, Jacek Wachowiak, Katarzyna Derwich, Olga Zając-Spychała

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引用次数: 0

Abstract

Neutropenia associated with onco-hematological treatment may contribute to high-mortality infections, especially caused by multidrug-resistant pathogens. In a 4-year-old girl treated due to early isolated central nervous system (CNS) relapse of B-cell acute lymphoblastic leukemia, skin lesions with traits of Fournier's gangrene caused by Klebsiella pneumoniae carbapenemase (KPC)-producing Pseudomonas aeruginosa (PsA). The patient was treated with broad-spectrum antibiotic therapy and the wound was debrided and treated with VAC (vacuum-assisted closure) successfully. Despite further intensive anticancer treatment complicated by reactivation of PsA infection, there was no other episode of invasive infection anymore and, nowadays, the patient has been in complete remission for 13 months. The aim of this report is to mention that Fournier's gangrene is a rapid and potentially fatal infectious complication of chemotherapy in onco-hematological pediatric patients, especially if caused by MDR (multidrug-resistant) pathogens. Successful treatment of this necrotizing fasciitis saves a patient's life and allows to continue an effective anticancer therapy.

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来源期刊

Infection and Drug Resistance Medicine-Pharmacology (medical)

CiteScore

5.60

自引率

7.70%

发文量

826

审稿时长

16 weeks

期刊介绍： About Journal Editors Peer Reviewers Articles Article Publishing Charges Aims and Scope Call For Papers ISSN: 1178-6973 Editor-in-Chief: Professor Suresh Antony An international, peer-reviewed, open access journal that focuses on the optimal treatment of infection (bacterial, fungal and viral) and the development and institution of preventative strategies to minimize the development and spread of resistance.