The hepatoprotective effect of Lonicera japonica Flos on rats with high-fat diet-induced non-alcoholic fatty liver disease

IF 2.5 3区医学 Q3 CHEMISTRY, MEDICINAL

Fitoterapia Pub Date : 2025-04-04 DOI:10.1016/j.fitote.2025.106516

Xue Ma, Chun-Yong Sun, Yan Zhang, Jia Li, Dong-Sheng Zhao

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引用次数: 0

Abstract

Lonicerae Japonica Flos (LJF) is an edible-medicinal herb, rich in phenolic acids, flavonoids, iridoids and other bioactive ingredients, that has anti-inflammatory, antioxidant, antilipemic, and hepatoprotective effects. However, its effect on non-alcoholic fatty liver disease (NAFLD) remains to be elucidated. The aim of this study was to determine the effect of LJF on liver injury in rats with high-fat diet (HFD)-induced NAFLD. The administration of LJF extract to rats with HFD-induced NAFLD significantly improved their body weight and daily food intake, liver tissue steatosis, lipid droplet vacuolization, and inflammatory cell infiltration. In addition, the LJF extract also improved to varying degrees the serum biochemical parameters, liver lipid content, levels of inflammatory factors, and oxidative stress markers. Among the treatment groups, the LJF high-dose group (LJF-H) showed the most significant improvement effect. Additionally, the correlation matrix heatmap visualization indicated that LJF may ameliorate NAFLD mainly by lowering liver lipid content and improving serum biochemical parameters.

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金银花对高脂饮食诱导的非酒精性脂肪性肝病大鼠的肝保护作用。

金银花（Lonicerae Japonica Flos， LJF）是一种可食用的药材，富含酚酸、黄酮类化合物、环烯醚萜等生物活性成分，具有抗炎、抗氧化、降脂、保肝等作用。然而，其对非酒精性脂肪性肝病（NAFLD）的影响仍有待阐明。本研究的目的是确定LJF对高脂饮食（HFD）诱导的NAFLD大鼠肝损伤的影响。枸芪提取物对hfd诱导的NAFLD大鼠的体重、日摄食量、肝组织脂肪变性、脂滴空泡化和炎症细胞浸润均有显著改善。此外，LJF提取物还不同程度地改善了血清生化指标、肝脏脂质含量、炎症因子水平和氧化应激标志物水平。各治疗组中，LJF高剂量组（LJF- h）改善效果最为显著。此外，相关矩阵热图可视化显示，LJF可能主要通过降低肝脏脂质含量和改善血清生化指标来改善NAFLD。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Fitoterapia 医学-药学

CiteScore

5.80

自引率

2.90%

发文量

198

审稿时长

1.5 months

期刊介绍： Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.