Successfully maintained complete remission of mycosis fungoides by umbilical cord blood transplantation: a case report and literature review.

IF 2.3 Q2 DERMATOLOGY
Munenari Itoh, Sayaka Oshima, Hiroto Ishii, Shingo Yano, Akihiko Asahina, Yoshimasa Nobeyama
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引用次数: 0

Abstract

Mycosis fungoides (MF) is a major variant of primary cutaneous T-cell lymphoma (CTCL) characterized by infiltration of neoplastic T cells in the epidermis and dermis. This disease progresses gradually and rarely reaches an advanced stage. Once advanced, MF is nearly impossible to treat due to limited therapeutic options. However, allogeneic hematopoietic stem cell transplantation (allo-HSCT) has recently emerged as a potential treatment. Among hematopoietic stem cell (HSC) sources, umbilical cord blood transplantation (UCBT) offers significant advantages. Despite its potential, there are challenges in applying UCBT to adults, and there are only a few reports on its use for MF. We report a Japanese case of advanced MF maintaining complete remission (CR) with UCBT and review previous cases of CTCL, including MF, treated with UCBT.

通过脐带血移植成功维持真菌病完全缓解:1例报告和文献复习。
蕈样真菌病(MF)是原发性皮肤T细胞淋巴瘤(CTCL)的一种主要变体,其特征是表皮和真皮中肿瘤T细胞的浸润。这种疾病进展缓慢,很少发展到晚期。一旦进展,由于治疗选择有限,MF几乎不可能治疗。然而,同种异体造血干细胞移植(alloo - hsct)最近成为一种潜在的治疗方法。在造血干细胞(HSC)来源中,脐带血移植(UCBT)具有显著的优势。尽管UCBT具有潜力,但将其应用于成人仍存在挑战,并且只有少数关于其用于MF的报道。我们报告了一例日本晚期MF患者通过UCBT维持完全缓解(CR),并回顾了以前的CTCL病例,包括MF,用UCBT治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Dermatology Reports
Dermatology Reports DERMATOLOGY-
CiteScore
1.40
自引率
0.00%
发文量
74
审稿时长
10 weeks
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