Review of the Efficacy and Mechanisms of Traditional Chinese Medicine for Treating Multi-Organ Damage in Wilson's Disease.

IF 4.7 2区医学 Q1 CHEMISTRY, MEDICINAL

Drug Design, Development and Therapy Pub Date : 2025-04-01 eCollection Date: 2025-01-01 DOI:10.2147/DDDT.S515123

Hong Chen, Xie Wang, Le Tang, Yue Pu, Ying Ma, Hao Ye, Juan Zhang

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引用次数: 0

Abstract

Wilson's disease (WD) is an autosomal recessive disorder characterized by abnormal copper metabolism. Disruptions in copper metabolism lead to excessive copper deposition in the liver, nervous system, kidneys, heart, and other organs, thereby inducing a range of pathological manifestations and clinical symptoms. Traditional Chinese Medicine (TCM) has demonstrated significant therapeutic efficacy and excellent safety profiles. When integrated with effective Western anti-copper therapies, it can yield superior therapeutic outcomes. Consequently, TCM has exhibited unique advantages in managing WD, particularly when combined with multiple systemic damages. This paper discusses the pathological mechanisms and TCM etiology and pathogenesis of WD combined with multiple organ damage. It also summarizes the clinical efficacy and mechanism of TCM in treating WD combined with multiple organ damage, aiming to provide a reference for further studies on the role and potential mechanisms of TCM interventions in WD.

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中药治疗肝豆状核变性多器官损害的疗效及机制研究进展。

威尔逊氏病（WD）是一种常染色体隐性遗传病，以铜代谢异常为特征。铜代谢紊乱导致过量的铜沉积在肝脏、神经系统、肾脏、心脏等器官，从而诱发一系列病理表现和临床症状。传统中药（TCM）已经证明了显著的治疗效果和良好的安全性。当与有效的西方抗铜疗法相结合时，可以产生更好的治疗效果。因此，中药在治疗WD方面表现出独特的优势，特别是在合并多种系统性损害时。本文就WD合并多脏器损害的病理机制及中医病因病机进行探讨。总结中医药治疗WD合并多脏器损害的临床疗效及机制，旨在为进一步研究中医药干预WD的作用及可能机制提供参考。

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来源期刊

Drug Design, Development and Therapy CHEMISTRY, MEDICINAL-PHARMACOLOGY & PHARMACY

CiteScore

9.00

自引率

0.00%

发文量

382

审稿时长

>12 weeks

期刊介绍： Drug Design, Development and Therapy is an international, peer-reviewed, open access journal that spans the spectrum of drug design, discovery and development through to clinical applications. The journal is characterized by the rapid reporting of high-quality original research, reviews, expert opinions, commentary and clinical studies in all therapeutic areas. Specific topics covered by the journal include: Drug target identification and validation Phenotypic screening and target deconvolution Biochemical analyses of drug targets and their pathways New methods or relevant applications in molecular/drug design and computer-aided drug discovery* Design, synthesis, and biological evaluation of novel biologically active compounds (including diagnostics or chemical probes) Structural or molecular biological studies elucidating molecular recognition processes Fragment-based drug discovery Pharmaceutical/red biotechnology Isolation, structural characterization, (bio)synthesis, bioengineering and pharmacological evaluation of natural products** Distribution, pharmacokinetics and metabolic transformations of drugs or biologically active compounds in drug development Drug delivery and formulation (design and characterization of dosage forms, release mechanisms and in vivo testing) Preclinical development studies Translational animal models Mechanisms of action and signalling pathways Toxicology Gene therapy, cell therapy and immunotherapy Personalized medicine and pharmacogenomics Clinical drug evaluation Patient safety and sustained use of medicines.