Influenza vaccine effectiveness among primary and secondary school students in Shenzhen during the 2023/24 influenza season.

IF 7.5 2区医学 Q1 IMMUNOLOGY

Emerging Microbes & Infections Pub Date : 2025-12-01 Epub Date: 2025-04-24 DOI:10.1080/22221751.2025.2490531

Yawen Jiang, Jiatong Sun, Fang Huang, Xu Xie, Xin Wang, Xiaoliang Wu, Min Jiang, Ying Sun, Hui Liu, Huiqiao Gu, Quan Lu, Xiaozhen Chen, Tiejian Feng, Shisong Fang, Jianhua Lu, Yuelong Shu

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Abstract

During the winter influenza peaks, a total of 2689 ILI patients were collected from the two hospitals, with 58.61% of the participants vaccinated. Of the ILI patients, 761 (28.3%) were laboratory-confirmed influenza infection, with 76.7% being A(H3N2) and 22.8% B/Victoria. After adjusting for covariates, the adjusted VE (aVE) was 57.06% (95% CI, 48.59-64.13%). In the subtype/lineage and age subgroup analysis, influenza VE against B/Victoria was higher than A(H3N2), and decreased with age. More, influenza VE (aVE = 19.63% [95% CI, -29.13-49.98%]) against all subtypes/lineages were not statistically significant for the spring-summer peak. Overall, influenza vaccines provided significant protection against influenza-associated outpatient visits among students in Shenzhen during 2023/24 winter influenza season. The findings underscore the importance of maintaining high vaccination coverage.

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2023/24年流感季节深圳市中小学生流感疫苗接种效果调查

有关中国大陆南部地区儿童接种流感疫苗有效性（VE）的证据仍然很少。为了评估2023/24流感季节深圳6-18岁学生的流感疫苗有效性，我们开展了一项检测阴性的病例对照研究。研究对象为在冬季流感高峰期前往两家指定医院就诊的具有流感样疾病（ILI）症状（急性发病，发热≥38°C，咽痛或咳嗽）的学生。数据通过调查问卷和口咽拭子收集，并在深圳市疾病预防控制中心进行rt-PCR检测。我们使用多重逻辑回归来调整协变量，包括性别、年龄、地理位置、基础疾病和上一季度的疫苗接种史。此外，我们还使用同样的方法对春夏季流感高峰期的流感VE进行了探索性评估。在冬季流感高峰期，两家医院共收集了2689名ILI患者，其中58.61%的参与者接种了疫苗。在流感ILI患者中，761人（28.3%）经实验室确诊感染了流感，其中76.7%为甲型（H3N2），22.8%为乙型/维多利亚型。调整协变量后，调整VE（aVE）为57.06%（95% CI，48.59 - 64.13%）。在亚型/系别和年龄亚组分析中，乙型/维多利亚型流感的VE高于甲型（H3N2）流感，并随着年龄的增长而降低。此外，在春夏季流感高峰期，所有亚型/系的流感VE（aVE = 19.63% [95% CI, -29.13 to 49.98%]）均无统计学意义。研究结果强调了保持高疫苗接种覆盖率的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Emerging Microbes & Infections IMMUNOLOGY-MICROBIOLOGY

CiteScore

26.20

自引率

2.30%

发文量

276

审稿时长

20 weeks

期刊介绍： Emerging Microbes & Infections is a peer-reviewed, open-access journal dedicated to publishing research at the intersection of emerging immunology and microbiology viruses. The journal's mission is to share information on microbes and infections, particularly those gaining significance in both biological and clinical realms due to increased pathogenic frequency. Emerging Microbes & Infections is committed to bridging the scientific gap between developed and developing countries. This journal addresses topics of critical biological and clinical importance, including but not limited to: - Epidemic surveillance - Clinical manifestations - Diagnosis and management - Cellular and molecular pathogenesis - Innate and acquired immune responses between emerging microbes and their hosts - Drug discovery - Vaccine development research Emerging Microbes & Infections invites submissions of original research articles, review articles, letters, and commentaries, fostering a platform for the dissemination of impactful research in the field.