The impact of depression on the quality of life of lung cancer patients undergoing chemotherapy: mediating effects of perceived social support.

IF 3.2 3区医学 Q2 PSYCHIATRY

Frontiers in Psychiatry Pub Date : 2025-03-21 eCollection Date: 2025-01-01 DOI:10.3389/fpsyt.2025.1526217

Fan Xu, Shaoju Xie, Qiao Li, Xiaoli Zhong, Jiquan Zhang

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引用次数: 0

Abstract

Background: Quality of life (QOL) in patients undergoing chemotherapy for lung cancer has been a key research area. Numerous studies have examined the relationships among depression, perceived social support (PSS), and QOL. However, the mechanisms underlying PSS in lung cancer patients receiving chemotherapy remain underexplored.

Objective: To investigate the mediating role of PSS in the relationship between depression and QOL in lung cancer patients undergoing chemotherapy.

Methods: A convenience sample of 390 lung cancer patients undergoing chemotherapy was selected from the outpatient clinics and wards of the Department of Oncology at a tertiary hospital in Deyang City between January 2024 and June 2024. Participants completed a general information questionnaire, Self-Rating Depression Scale (SDS), Multidimensional Scale of Perceived Social Support (MPSSS), and Functional Assessment of Cancer Therapy-Lung Cancer (FACT-L) scale. SPSS 26.0 was used to analyze correlations between depression, PSS, and QOL, while AMOS 26.0 assessed the mediating effect of PSS on the relationship between depression and QOL.

Results: The mean scores for depression, PSS, and QOL were 39.79 ± 11.63, 68.96 ± 13.09, and 66.43 ± 23.67, respectively. Pearson's correlation analysis showed that depression was negatively correlated with QOL (r = -0.319, P < 0.001) and positively correlated with PSS (r = -0.484, P < 0.001). Additionally, PSS was positively correlated with QOL (r = 0.349, P < 0.001). PSS partially mediated the relationship between depression and QOL, with a mediating effect value of -0.165, accounting for 50.3% of the total effect.

Conclusion: Depression in lung cancer patients undergoing chemotherapy directly impacts QOL and indirectly affects it through PSS. Clinically, healthcare providers should address depression in these patients and offer psychological support and interventions as needed. Additionally, medical institutions can implement targeted strategies to help patients build a strong social support system, reduce negative emotions, enhance psychological well-being, and improve overall QOL.

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抑郁对肺癌化疗患者生活质量的影响：感知社会支持的中介作用

研究背景肺癌化疗患者的生活质量（QOL）一直是一个重要的研究领域。许多研究探讨了抑郁、感知社会支持（PSS）和 QOL 之间的关系。然而，对肺癌化疗患者感知到的社会支持（PSS）的作用机制仍未进行深入探讨：调查 PSS 在接受化疗的肺癌患者抑郁与 QOL 关系中的中介作用：在 2024 年 1 月至 2024 年 6 月期间，从德阳市某三级甲等医院肿瘤科门诊和病房抽取 390 名正在接受化疗的肺癌患者作为方便样本。参与者填写了一般信息问卷、抑郁自评量表（SDS）、感知社会支持多维量表（MPSSS）和癌症治疗功能评估-肺癌量表（FACT-L）。使用 SPSS 26.0 分析抑郁、PSS 和 QOL 之间的相关性，而 AMOS 26.0 则评估 PSS 对抑郁和 QOL 之间关系的中介效应：抑郁、PSS 和 QOL 的平均得分分别为（39.79 ± 11.63）、（68.96 ± 13.09）和（66.43 ± 23.67）。皮尔逊相关分析显示，抑郁与 QOL 呈负相关（r = -0.319，P < 0.001），与 PSS 呈正相关（r = -0.484，P < 0.001）。此外，PSS 与 QOL 呈正相关（r = 0.349，P < 0.001）。PSS部分介导了抑郁与QOL之间的关系，介导效应值为-0.165，占总效应的50.3%：结论：肺癌化疗患者的抑郁会直接影响 QOL，并通过 PSS 间接影响 QOL。临床上，医护人员应正视这些患者的抑郁问题，并根据需要提供心理支持和干预。此外，医疗机构可实施有针对性的策略，帮助患者建立强大的社会支持系统，减少负面情绪，提高心理健康水平，改善整体 QOL。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Psychiatry Medicine-Psychiatry and Mental Health

CiteScore

6.20

自引率

8.50%

发文量

2813

审稿时长

14 weeks

期刊介绍： Frontiers in Psychiatry publishes rigorously peer-reviewed research across a wide spectrum of translational, basic and clinical research. Field Chief Editor Stefan Borgwardt at the University of Basel is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. The journal''s mission is to use translational approaches to improve therapeutic options for mental illness and consequently to improve patient treatment outcomes.