{"title":"Secular trends in the incidence of atrial fibrillation across different ages and genders in Taiwan from 2001 to 2021.","authors":"Chi-Hsun Lien, Kung-Cheng Hsu, Yu-Kang Chang, Chien-Jung Chang, Ying-Ming Chiu, Hung-Yi Hsu","doi":"10.1016/j.hrthm.2025.03.2001","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Atrial fibrillation (AF), the most prevalent arrhythmia, is associated with an increased risk of stroke, systemic embolism, and death.</p><p><strong>Objectives: </strong>This study aimed to investigate the secular trends in AF incidence rates (IRs) among different age, gender and comorbiditysubgroups in a Chinese population from 2000 to 2021.</p><p><strong>Methods: </strong>This retrospective study used data from the National Health Insurance Research Database in Taiwan, determined AF cases using the International Classification of Diseases, 9<sup>th</sup> and 10<sup>th</sup> Revision, Clinical Modification codes, and calculated and stratified the annual age-standardized IRs by age, gender, and comorbidity status.</p><p><strong>Results: </strong>The total number of AF cases increased from 24,450 in 2000 to 32,817 in 2021, while the standardized IR (SIR) decreased from 170.62 to 112.38 per 100,000 person-years. Males demonstrated higher IRs than females across all age groups. The annual IRs substantially increased with age. IRs exhibited a declining trend, except in males aged 20-49 years and females aged 20-34 years. The trends of SIRs showed distinct patterns among patients with different comorbidity burdens. Individuals with lower comorbidity burden demonstrated lower SIRs and earlier declines in SIRs.</p><p><strong>Conclusion: </strong>This study reveals complex secular trends of AF incidence in the past 21 years, with decreasing overall SIRs but increasing annual IRs in younger populations. The intricate interplay between AF incidence, age, and gender emphasizes the need for age- and sex-specific strategies in AF prevention and management. The observed relationship between comorbidity burden and AF incidences suggests differential effectiveness of cardiovascular risk management across patient subgroups.</p>","PeriodicalId":12886,"journal":{"name":"Heart rhythm","volume":" ","pages":""},"PeriodicalIF":5.6000,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Heart rhythm","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.hrthm.2025.03.2001","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Atrial fibrillation (AF), the most prevalent arrhythmia, is associated with an increased risk of stroke, systemic embolism, and death.
Objectives: This study aimed to investigate the secular trends in AF incidence rates (IRs) among different age, gender and comorbiditysubgroups in a Chinese population from 2000 to 2021.
Methods: This retrospective study used data from the National Health Insurance Research Database in Taiwan, determined AF cases using the International Classification of Diseases, 9th and 10th Revision, Clinical Modification codes, and calculated and stratified the annual age-standardized IRs by age, gender, and comorbidity status.
Results: The total number of AF cases increased from 24,450 in 2000 to 32,817 in 2021, while the standardized IR (SIR) decreased from 170.62 to 112.38 per 100,000 person-years. Males demonstrated higher IRs than females across all age groups. The annual IRs substantially increased with age. IRs exhibited a declining trend, except in males aged 20-49 years and females aged 20-34 years. The trends of SIRs showed distinct patterns among patients with different comorbidity burdens. Individuals with lower comorbidity burden demonstrated lower SIRs and earlier declines in SIRs.
Conclusion: This study reveals complex secular trends of AF incidence in the past 21 years, with decreasing overall SIRs but increasing annual IRs in younger populations. The intricate interplay between AF incidence, age, and gender emphasizes the need for age- and sex-specific strategies in AF prevention and management. The observed relationship between comorbidity burden and AF incidences suggests differential effectiveness of cardiovascular risk management across patient subgroups.
期刊介绍：
HeartRhythm, the official Journal of the Heart Rhythm Society and the Cardiac Electrophysiology Society, is a unique journal for fundamental discovery and clinical applicability.
HeartRhythm integrates the entire cardiac electrophysiology (EP) community from basic and clinical academic researchers, private practitioners, engineers, allied professionals, industry, and trainees, all of whom are vital and interdependent members of our EP community.
The Heart Rhythm Society is the international leader in science, education, and advocacy for cardiac arrhythmia professionals and patients, and the primary information resource on heart rhythm disorders. Its mission is to improve the care of patients by promoting research, education, and optimal health care policies and standards.
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