Ferroptosis in neurodegenerative diseases: mechanisms and therapeutic potential of stem cell derivatives.

IF 4.6 2区生物学 Q2 CELL BIOLOGY

Frontiers in Cell and Developmental Biology Pub Date : 2025-03-21 eCollection Date: 2025-01-01 DOI:10.3389/fcell.2025.1577382

Ting Zhang, Yusu Zhang, Jinpeng Xie, Dandan Lu, Lihong Wang, Shuaifei Zhao, Jing Zhou, Yang Cheng, Ting Kou, Jue Wang, Ying Chen, Lei Xu, Xiangyu Hu, Yuxiu Ying, Jun Wang, Xiaoshuang Xin, Xu Xu, Siyun Lei, Chenyu Qiu, Jinhua Wu, Qiqi Lyu, Tong Cao

引用次数: 0

Abstract

Ferroptosis, a non-apoptotic, iron-dependent form of regulated cell death, is closely related to the pathogenesis of neurodegenerative diseases. Stem cells and their derivatives exhibit remarkable potential in modulating ferroptosis, offering promising therapeutic intervention for neurodegenerative diseases. In this review, we systematically explore neurological aging and its association with cognitive impairment and neurodegenerative diseases, with focus on the molecular mechanisms of ferroptosis in neurodegenerative diseases and the potential therapeutic strategies of stem cell derivatives for neurological diseases.

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来源期刊

Frontiers in Cell and Developmental Biology Biochemistry, Genetics and Molecular Biology-Cell Biology

CiteScore

9.70

自引率

3.60%

发文量

2531

审稿时长

12 weeks

期刊介绍： Frontiers in Cell and Developmental Biology is a broad-scope, interdisciplinary open-access journal, focusing on the fundamental processes of life, led by Prof Amanda Fisher and supported by a geographically diverse, high-quality editorial board. The journal welcomes submissions on a wide spectrum of cell and developmental biology, covering intracellular and extracellular dynamics, with sections focusing on signaling, adhesion, migration, cell death and survival and membrane trafficking. Additionally, the journal offers sections dedicated to the cutting edge of fundamental and translational research in molecular medicine and stem cell biology. With a collaborative, rigorous and transparent peer-review, the journal produces the highest scientific quality in both fundamental and applied research, and advanced article level metrics measure the real-time impact and influence of each publication.