Nano-Enabled Effective Tuberculosis Treatments: A Concise Overview.

IF 5.4 2区医学 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Biomaterials Science & Engineering Pub Date : 2025-04-07 DOI:10.1021/acsbiomaterials.4c02109

Jingjing Li, Huxiao Sun, Dzmitry Shcharbin, Serge Mignani, Jean-Pierre Majoral, Mingwu Shen, Xiangyang Shi

引用次数: 0

Abstract

Tuberculosis (TB) is a severe respiratory infectious disease caused by Mycobacterium tuberculosis (M.tb), which puts enormous pressure on public health and economic systems worldwide. Therefore, accurate diagnosis and timely intervention of TB are critical for interrupting disease transmission and reducing mortality among TB patients. However, the low bioavailability, inadequate targeting, and significant adverse side effects of conventional antibiotics and the emergence of the multidrug-resistant M.tb strain result in limited TB treatment efficacy or even the development of multidrug-resistant TB. The development of nanomaterials provides new perspectives to improve the drawbacks of antibiotics for improved TB treatment, while enabling the diagnosis of TB. Herein, we review the conventional and nanotechnology-based diagnosis and intervention strategy of TB and the currently developed novel methods to solve the TB dilemma.

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结核病（TB）是由结核分枝杆菌（M.tb）引起的严重呼吸道传染病，给全球公共卫生和经济系统带来巨大压力。因此，准确诊断和及时干预结核病对于阻断疾病传播和降低结核病患者死亡率至关重要。然而，传统抗生素生物利用度低、靶向性不足、不良副作用大，以及耐多药结核菌株的出现，导致结核病治疗效果有限，甚至出现耐多药结核病。纳米材料的发展为改善抗生素的弊端，提高结核病治疗效果，同时实现结核病诊断提供了新的视角。在此，我们回顾了结核病的传统诊断和干预策略、基于纳米技术的诊断和干预策略以及目前为解决结核病困境而开发的新型方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Biomaterials Science & Engineering Materials Science-Biomaterials

CiteScore

10.30

自引率

3.40%

发文量

413

期刊介绍： ACS Biomaterials Science & Engineering is the leading journal in the field of biomaterials, serving as an international forum for publishing cutting-edge research and innovative ideas on a broad range of topics: Applications and Health – implantable tissues and devices, prosthesis, health risks, toxicology Bio-interactions and Bio-compatibility – material-biology interactions, chemical/morphological/structural communication, mechanobiology, signaling and biological responses, immuno-engineering, calcification, coatings, corrosion and degradation of biomaterials and devices, biophysical regulation of cell functions Characterization, Synthesis, and Modification – new biomaterials, bioinspired and biomimetic approaches to biomaterials, exploiting structural hierarchy and architectural control, combinatorial strategies for biomaterials discovery, genetic biomaterials design, synthetic biology, new composite systems, bionics, polymer synthesis Controlled Release and Delivery Systems – biomaterial-based drug and gene delivery, bio-responsive delivery of regulatory molecules, pharmaceutical engineering Healthcare Advances – clinical translation, regulatory issues, patient safety, emerging trends Imaging and Diagnostics – imaging agents and probes, theranostics, biosensors, monitoring Manufacturing and Technology – 3D printing, inks, organ-on-a-chip, bioreactor/perfusion systems, microdevices, BioMEMS, optics and electronics interfaces with biomaterials, systems integration Modeling and Informatics Tools – scaling methods to guide biomaterial design, predictive algorithms for structure-function, biomechanics, integrating bioinformatics with biomaterials discovery, metabolomics in the context of biomaterials Tissue Engineering and Regenerative Medicine – basic and applied studies, cell therapies, scaffolds, vascularization, bioartificial organs, transplantation and functionality, cellular agriculture