Sex and Sleep Quality Effects on the Relationship Between Sleep Disruption and Pain Sensitivity

IF 3.5 2区医学 Q1 ANESTHESIOLOGY

European Journal of Pain Pub Date : 2025-04-08 DOI:10.1002/ejp.70023

Elisabet Dortea Ragnvaldsdóttir Joensen, Laura Frederiksen, Signe Vindbæk Frederiksen, Emilie Stjernholm Valeur, Rocco Giordano, Emma Hertel, Kristian Kjær-Staal Petersen

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Abstract

Background

Chronic pain affects around 20% of the global population and is influenced by various factors, including sleep quality. Studies indicate that sleep disruption can enhance pain sensitivity; however, it is unclear how sex and baseline sleep quality impact these findings. This study examines how sex and baseline sleep quality impact the effects of three nights of sleep disruption on pain sensitivity in healthy individuals.

Methods

Fifty-nine participants (30 females) underwent two laboratory sessions, separated by three nights of sleep disruption. Pain sensitivity was measured using cuff and handheld algometry, and participants completed a battery of questionnaires on sleep quality, positive and negative affect, and pain catastrophising. Sleep patterns were collected through wrist actigraphy and self-reported sleep diaries.

Results

Temporal summation of pain was significantly facilitated in males (p < 0.01), and pain during suprathreshold stimulation was increased for females (p < 0.01) after the experimental sleep disruption. No differences in any QST parameters were found when comparing participants with good or poor sleep at baseline, but those with good baseline sleep rated the suprathreshold stimulation as more painful (p < 0.05) after the experimental sleep disruption. Finally, having good or poor sleep quality at baseline was associated with a significant reduction in self-reported sleep quality and level of rest after the experimental sleep disruption (p < 0.05).

Conclusion

This study indicates that sleep disruption might impact sexes differently and indicates that prior sleep quality is less likely to impact this.

Significance

Sleep disruption protocols can mimic the sleep problems experienced by patients with chronic pain. The current study explains how different sexes respond to a 3-night sleep disruption protocol and explains how sleep quality at baseline might impact these results.

Abstract Image

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性别和睡眠质量对睡眠中断和疼痛敏感性关系的影响

慢性疼痛影响着全球约20%的人口，并受到包括睡眠质量在内的各种因素的影响。研究表明，睡眠中断可以增强疼痛敏感性；然而，尚不清楚性别和基线睡眠质量如何影响这些发现。这项研究考察了性别和基线睡眠质量如何影响健康个体连续三晚睡眠中断对疼痛敏感性的影响。方法59名参与者（30名女性）进行了两次实验，间隔三晚睡眠中断。研究人员使用袖带和手持式测痛仪来测量疼痛敏感性，参与者还完成了一系列关于睡眠质量、积极和消极影响以及疼痛灾难的问卷调查。通过腕部活动记录仪和自我报告的睡眠日记收集睡眠模式。结果实验睡眠中断后，男性疼痛的时间累积明显增加（p < 0.01），女性阈上刺激时的疼痛增加（p < 0.01）。在比较基线睡眠质量好或差的参与者时，没有发现任何QST参数的差异，但基线睡眠质量好的参与者在实验睡眠中断后认为阈值以上刺激更痛苦（p < 0.05）。最后，基线睡眠质量好或差与实验性睡眠中断后自我报告的睡眠质量和休息水平显著降低相关（p < 0.05）。这项研究表明，睡眠中断可能对性别产生不同的影响，而先前的睡眠质量不太可能影响这一点。睡眠中断方案可以模拟慢性疼痛患者的睡眠问题。目前的研究解释了不同性别对三晚睡眠中断方案的反应，并解释了基线睡眠质量如何影响这些结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Pain 医学-临床神经学

CiteScore

7.50

自引率

5.60%

发文量

163

审稿时长

4-8 weeks

期刊介绍： European Journal of Pain (EJP) publishes clinical and basic science research papers relevant to all aspects of pain and its management, including specialties such as anaesthesia, dentistry, neurology and neurosurgery, orthopaedics, palliative care, pharmacology, physiology, psychiatry, psychology and rehabilitation; socio-economic aspects of pain are also covered. Regular sections in the journal are as follows: • Editorials and Commentaries • Position Papers and Guidelines • Reviews • Original Articles • Letters • Bookshelf The journal particularly welcomes clinical trials, which are published on an occasional basis. Research articles are published under the following subject headings: • Neurobiology • Neurology • Experimental Pharmacology • Clinical Pharmacology • Psychology • Behavioural Therapy • Epidemiology • Cancer Pain • Acute Pain • Clinical Trials.