Age Differences in Brain Functional Connectivity Underlying Proactive Interference in Working Memory

IF 3.5 2区 医学 Q1 NEUROIMAGING
P. Andersson, M. G. S. Schrooten, J. Persson
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Abstract

Aging is typically accompanied by a decline in working memory (WM) capacity, even in the absence of pathology. Proficient WM requires cognitive control processes that can retain goal-relevant information for easy retrieval and resolve interference from irrelevant information. Aging has been associated with a reduced ability to resolve proactive interference (PI) in WM, leading to impaired retrieval of goal-relevant information. It remains unclear how age-related differences in the ability to resolve PI in WM are related to patterns of resting-state functional connectivity (rsFC) in the brain. Here, we investigated the association between PI in WM and rsFC cross-sectionally (n = 237) and 5 years longitudinally (n = 134) across the adult life span by employing both seed-based and data-driven approaches. Results revealed that the ability to resolve PI was associated with differential patterns of inferior frontal gyrus (IFG) rsFC in younger/middle-aged adults (25–60 years) and older adults (65–80 years) in two clusters centered in the vermis and caudate. Specifically, more PI was associated with stronger inferior frontal gyrus—vermis connectivity and weaker inferior frontal gyrus—caudate connectivity in older adults, while younger/middle-aged adults showed associations in the opposite directions with the identified clusters. Longitudinal analyses revealed that a reduced ability to control PI was associated with reduced inferior frontal gyrus—insula and inferior frontal gyrus—anterior cingulate cortex connectivity in older adults, while younger/middle-aged adults showed associations in the opposite direction with these clusters. Whole brain multivariate pattern analyses showed age-differential patterns of rsFC indicative of age-related structural decline and age-related compensation. The current results show that rsFC is associated with the ability to control PI in WM and that these associations are modulated by age.

Abstract Image

工作记忆主动干扰下脑功能连通性的年龄差异
衰老通常伴随着工作记忆(WM)能力的下降,即使在没有病理的情况下。熟练的WM要求认知控制过程能够保留目标相关信息以便于检索,并解决不相关信息的干扰。衰老与WM中解决主动干扰(PI)的能力下降有关,导致对目标相关信息的检索受损。目前尚不清楚WM中解决PI能力的年龄相关差异如何与大脑静息状态功能连接(rsFC)模式相关。在这里,我们通过采用基于种子和数据驱动的方法,研究了横断面(n = 237)和纵向5年(n = 134)在整个成人生命周期中WM和rsFC的PI之间的关系。结果显示,在年轻/中年成人(25-60岁)和老年人(65-80岁)中,解决PI的能力与以蚓部和尾状核为中心的两个簇的下额回(IFG) rsFC的不同模式有关。具体来说,在老年人中,更多的PI与更强的额下回-蚓部连通性和更弱的额下回-尾状核连通性相关,而年轻/中年成年人与所识别的簇呈相反方向的关联。纵向分析显示,老年人控制PI能力的降低与额下回-脑岛和额下回-前扣带皮层连通性的降低有关,而年轻人/中年人与这些集群的联系则相反。全脑多变量模式分析显示rsFC的年龄差异模式表明年龄相关的结构衰退和年龄相关的代偿。目前的结果表明,在WM中,rsFC与控制PI的能力有关,并且这些关联受年龄的调节。
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来源期刊
Human Brain Mapping
Human Brain Mapping 医学-核医学
CiteScore
8.30
自引率
6.20%
发文量
401
审稿时长
3-6 weeks
期刊介绍: Human Brain Mapping publishes peer-reviewed basic, clinical, technical, and theoretical research in the interdisciplinary and rapidly expanding field of human brain mapping. The journal features research derived from non-invasive brain imaging modalities used to explore the spatial and temporal organization of the neural systems supporting human behavior. Imaging modalities of interest include positron emission tomography, event-related potentials, electro-and magnetoencephalography, magnetic resonance imaging, and single-photon emission tomography. Brain mapping research in both normal and clinical populations is encouraged. Article formats include Research Articles, Review Articles, Clinical Case Studies, and Technique, as well as Technological Developments, Theoretical Articles, and Synthetic Reviews. Technical advances, such as novel brain imaging methods, analyses for detecting or localizing neural activity, synergistic uses of multiple imaging modalities, and strategies for the design of behavioral paradigms and neural-systems modeling are of particular interest. The journal endorses the propagation of methodological standards and encourages database development in the field of human brain mapping.
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